NDLI: Potential clinical utility of advanced glycation end product cross-link breakers in age- and diabetes-associated disorders.

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Potential clinical utility of advanced glycation end product cross-link breakers in age- and diabetes-associated disorders.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yamagishi, Sho-ichi
Description	Country affiliation: Japan Author Affiliation: Yamagishi S ( Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume 830-0011, Japan. shoichi@med.kurume-u.ac.jp)
Abstract	Reducing sugars can react nonenzymatically with the amino groups of proteins to form Amadori products. These early glycation products undergo further complex reactions, such as rearrangement, dehydration, and condensation, to become irreversibly cross-linked, heterogeneous fluorescent derivatives, termed advanced glycation end products (AGEs). The formation and accumulation of AGEs have been known to progress in a normal aging process and at an accelerated rate under diabetes. Nonenzymatic glycation and cross-linking of proteins not only leads to an increase in vascular and myocardial stiffness, but also deteriorates structural integrity and physiological function of multiple organ systems. Furthermore, there is accumulating evidence that interaction of AGEs with a cell-surface receptor, receptor for AGEs (RAGE), elicits oxidative stress generation and subsequently evokes inflammatory, thrombogenic, and fibrotic reactions, thereby being involved in atherosclerosis, diabetic microvascular complications, erectile dysfunction, and pancreatic ß-cell apoptosis. Recently, AGE cross-link breakers have been discovered. Therefore, removal of the preexisting AGEs by the breakers has emerged as a novel therapeutic approach to various types of diseases that develop with aging. This article summarizes the potential clinical utility of AGE cross-link breakers in the prevention and management of age- and diabetes-associated disorders.
File Format	HTM / HTML
ISSN	15491684
e-ISSN	15578577
Journal	Rejuvenation Research
Issue Number	6
Volume Number	15
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2012-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Discipline Geriatrics Aging Metabolism Cross-linking Reagents Pharmacology Diabetes Complications Glycosylation End Products, Advanced Animals Thiazoles Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Aging Geriatrics and Gerontology

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