NDLI: Somatic polyploidization and cellular proliferation drive body size evolution in nematodes.

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Somatic polyploidization and cellular proliferation drive body size evolution in nematodes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Flemming, A. J. Shen, Z. Z. Cunha, A. Emmons, S. W. Leroi, A. M.
Description	Author Affiliation: Flemming AJ ( Department of Biology, Imperial College at Silwood Park, Ascot, Berkshire, SL5 7PY, United Kingdom.);
Abstract	Most of the hypodermis of a rhabditid nematode such as Caenorhabditis elegans is a single syncytium. The size of this syncytium (as measured by body size) has evolved repeatedly in the rhabditid nematodes. Two cellular mechanisms are important in the evolution of body size: changes in the numbers of cells that fuse with the syncytium, and the extent of its acellular growth. Thus nematodes differ from mammals and other invertebrates in which body size evolution is caused by changes in cell number alone. The evolution of acellular syncytial growth in nematodes is also associated with changes in the ploidy of hypodermal nuclei. These nuclei are polyploid as a consequence of iterative rounds of endoreduplication, and this endocycle has evolved repeatedly. The association between acellular growth and endoreduplication is also seen in C. elegans mutations that interrupt transforming growth factor-beta signaling and that result in dwarfism and deficiencies in hypodermal ploidy. The transforming growth factor-beta pathway is a candidate for being involved in nematode body size evolution.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Biological Evolution Body Constitution Genetics Nematoda Anatomy & Histology Polyploidy Rhabditida Animals Caenorhabditis Elegans Cell Division DNA, Helminth Invertebrates Mammals Cytology Ploidies Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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