NDLI: Genetically targeted cell disruption in Caenorhabditis elegans.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1997 Volume: 94 Issue: 26

Year: 1997 Volume: 94 Issue: 25

Year: 1997 Volume: 94 Issue: 24

Approximation algorithms.

Core geophysics.

The elusive singularity.

Estimating the probability of initiated cell death before tumor induction.

Global variation in the genetic and biochemical basis of diamondback moth resistance to Bacillus thuringiensis.

Estrogenic responses in estrogen receptor-alpha deficient mice reveal a distinct estrogen signaling pathway.

KSR stimulates Raf-1 activity in a kinase-independent manner.

A link between protein structure and enzyme catalyzed hydrogen tunneling.

The carbamate kinase-like carbamoyl phosphate synthetase of the hyperthermophilic archaeon Pyrococcus furiosus, a missing link in the evolution of carbamoyl phosphate biosynthesis.

The diversity and evolutionary relationships of the pregnancy-associated glycoproteins, an aspartic proteinase subfamily consisting of many trophoblast-expressed genes.

Localization and activity of lysyl oxidase within nuclei of fibrogenic cells.

Identification of specific Rp-phosphate oxygens in the tRNA anticodon loop required for ribosomal P-site binding.

Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein.

Isolation and bacterial expression of a sesquiterpene synthase cDNA clone from peppermint (Mentha x piperita, L.) that produces the aphid alarm pheromone (E)-β-farnesene

Anti-idiotype RNA selected with an anti-nuclear export signal antibody is actively transported in oocytes and inhibits Rev- and cap-dependent RNA export.

Functional analysis of DNA bending and unwinding by the high mobility group domain of LEF-1.

Inhibition of regulator of G protein signaling function by two mutant RGS4 proteins.

Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol.

An interaction between DNA ligase I and proliferating cell nuclear antigen: implications for Okazaki fragment synthesis and joining.

Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine.

Construction of a Z-DNA-specific restriction endonuclease.

Disruption of the murine gene encoding phosphatidylethanolamine N-methyltransferase.

Myc represses transcription of the growth arrest gene gas1.

Proteins on ribosome surface: measurements of protein exposure by hot tritium bombardment technique.

Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II.

Inhibition of NF-kappaB DNA binding and nitric oxide induction in human T cells and lung adenocarcinoma cells by selenite treatment.

P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity.

cAMP receptor protein-cAMP plays a crucial role in glucose-lactose diauxie by activating the major glucose transporter gene in Escherichia coli.

Cloning and expression of rat 25-hydroxyvitamin D3-1alpha-hydroxylase cDNA.

Cloning and expression of a cDNA encoding a bovine brain brefeldin A-sensitive guanine nucleotide-exchange protein for ADP-ribosylation factor.

Phagocytosis of rod outer segments by retinal pigment epithelial cells requires αvβ5 integrin for binding but not for internalization

Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase.

Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase.

In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone.

The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation.

Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization.

Erythrocyte membrane vesiculation: model for the molecular mechanism of protein sorting.

Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins.

Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): Characterization of connective tissue growth factor as a member of the IGFBP superfamily

Ol-Prx 3, a member of an additional class of homeobox genes, is unimodally expressed in several domains of the developing and adult central nervous system of the medaka (Oryzias latipes).

Homeobox gene Prx3 expression in rodent brain and extraneural tissues.

Genes regulated by androgen in the rat ventral prostate.

The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization.

The role of thyroid hormone in zebrafish and axolotl development.

Siamois is required for formation of Spemann's organizer.

Primate species richness is determined by plant productivity: implications for conservation.

Determining divergence times with a protein clock: update and reevaluation.

Rapid decline of fitness in panmictic populations of Drosophila melanogaster maintained under relaxed natural selection.

Plasmodium falciparum antigenic diversity: evidence of clonal population structure.

A gene-culture coevolutionary model for brother-sister mating.

Sequence variation in the Fanconi anemia gene FAA.

Yeast microarrays for genome wide parallel genetic and gene expression analysis.

Analysis of a peptide hormone-receptor interaction in the yeast two-hybrid system.

The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains.

Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing.

The yeast Cac1 protein is required for the stable inheritance of transcriptionally repressed chromatin at telomeres.

Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.

All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae

A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid system.

Molecular characterization of four induced alleles at the Ednrb locus.

TnTIN and TnTAP: mini-transposons for site-specific proteolysis in vivo.

Direct repeat sequences in the Streptomyces chitinase-63 promoter direct both glucose repression and chitin induction.

Recombination-dependent deletion formation in mammalian cells deficient in the nucleotide excision repair gene ERCC1.

Genetically targeted cell disruption in Caenorhabditis elegans.

Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: a fluorescence resonance energy transfer study.

Natural killer cell lines kill autologous beta2-microglobulin-deficient melanoma cells: implications for cancer immunotherapy.

Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway.

Btk dosage determines sensitivity to B cell antigen receptor cross-linking

CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling

Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH.

Preferential activation of the p46 isoform of JNK/SAPK in mouse macrophages by TNF alpha.

Interleukin 9: a candidate gene for asthma.

The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments.

Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice.

Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy.

Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis.

Loss of ovarian function promotes angiogenesis in human ovarian carcinoma.

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism.

A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse).

Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice.

An epidemic of tuberculosis with a high rate of tuberculin anergy among a population previously unexposed to tuberculosis, the Yanomami Indians of the Brazilian Amazon.

Overexpressed human CD44s promotes lung colonization during micrometastasis of murine fibrosarcoma cells: facilitated retention in the lung vasculature.

Murine hematopoietic reconstitution after tagging and selection of retrovirally transduced bone marrow cells.

Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors.

Inactivation of the alpha C protein antigen gene, bca, by a novel shuttle/suicide vector results in attenuation of virulence and immunity in group B Streptococcus.

CooB plays a chaperone-like role for the proteins involved in formation of CS1 pili of enterotoxigenic Escherichia coli

Electrophysiological studies on rat dorsal root ganglion neurons after peripheral axotomy: changes in responses to neuropeptides.

Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease.

The synthesis of ATP by glycolytic enzymes in the postsynaptic density and the effect of endogenously generated nitric oxide.

Neurotrophin release by neurotrophins: Implications for activity-dependent neuronal plasticity

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.

A hierarchical neuronal network for planning behavior.

Role of intrinsic synaptic circuitry in collicular sensorimotor integration.

A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons.

Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice.

$G_{i}$ regulation of secretory vesicle swelling examined by atomic force microscopy

Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: Role of inactivation

Basolateral membrane targeting of a renal-epithelial inwardly rectifying potassium channel from the cortical collecting duct, CCD-IRK3, in MDCK cells.

Killing K Channels with $TEA^{+}$

Australian lungfish neurohypophysial hormone genes encode vasotocin and [Phe2]mesotocin precursors homologous to tetrapod-type precursors.

A deletion in an indole synthase gene is responsible for the DIMBOA-deficient phenotype of bxbx maize.

ATPases and phosphate exchange activities in magnesium chelatase subunits of Rhodobacter sphaeroides

Phytosulfokine-alpha, a sulfated pentapeptide, stimulates the proliferation of rice cells by means of specific high- and low-affinity binding sites.

Brain activity in visual cortex predicts individual differences in reading performance.

Appendicular robusticity and the paleobiology of modern human emergence.

Advances in apoptosis research.

Encoding strategies in combinatorial chemistry.

Neural codes: firing rates and beyond.

Gene therapy. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 94 Issue: 24)

Motor proteins of the eukaryotic cytoskeleton.

Scanning-probe-based science and technology.

Fun with genealogy.

Life without DNA repair.

Origins of mRNA identity: capping enzymes bind to the phosphorylated C-terminal domain of RNA polymerase II.

Year: 1997 Volume: 94 Issue: 23

Year: 1997 Volume: 94 Issue: 22

Year: 1997 Volume: 94 Issue: 21

Year: 1997 Volume: 94 Issue: 20

Year: 1997 Volume: 94 Issue: 19

Year: 1997 Volume: 94 Issue: 18

Year: 1997 Volume: 94 Issue: 17

Year: 1997 Volume: 94 Issue: 16

Year: 1997 Volume: 94 Issue: 15

Year: 1997 Volume: 94 Issue: 14

Year: 1997 Volume: 94 Issue: 13

Year: 1997 Volume: 94 Issue: 12

Year: 1997 Volume: 94 Issue: 11

Year: 1997 Volume: 94 Issue: 10

Year: 1997 Volume: 94 Issue: 9

Year: 1997 Volume: 94 Issue: 8

Year: 1997 Volume: 94 Issue: 7

Year: 1997 Volume: 94 Issue: 6

Year: 1997 Volume: 94 Issue: 5

Year: 1997 Volume: 94 Issue: 4

Year: 1997 Volume: 94 Issue: 3

Year: 1997 Volume: 94 Issue: 2

Year: 1997 Volume: 94 Issue: 1

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Genetically targeted cell disruption in Caenorhabditis elegans.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xu, S. Q. Kinnell, M. Harbinder, S. Driscoll, M. Fire, A. Herndon, L. A. Tavernarakis, N.
Description	Author Affiliation: Harbinder S ( Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Center for Advanced Biotechnology and Medicine, Piscataway 08855, USA.);
Abstract	The elimination of identified cells is a powerful tool for investigating development and system function. Here we report on genetically mediated cell disruption effected by the toxic Caenorhabditis elegans mec-4(d) allele. We found that ectopic expression of mec-4(d) in the nematode causes dysfunction of a wide range of nerve, muscle, and hypodermal cells. mec-4(d)-mediated toxicity is dependent on the activity of a second gene, mec-6, rendering cell disruption conditionally dependent on genetic background. We describe a set of mec-4(d) vectors that facilitate construction of cell-specific disruption reagents and note that genetic cell disruption can be used for functional analyses of specific neurons or neuronal classes, for confirmation of neuronal circuitry, for generation of nematode populations lacking defined classes of functional cells, and for genetic screens. We suggest that mec-4(d) and/or related genes may be effective general tools for cell inactivation that could be used toward similar purposes in higher organisms.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Caenorhabditis Elegans Proteins Caenorhabditis Elegans Genetics Helminth Proteins Membrane Proteins Animals Cytology DNA, Helminth Genetic Vectors Interneurons Molecular Sequence Data Motor Neurons Neurons, Afferent Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in