NDLI: Nuclear structure in normal and Bloom syndrome cells.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 2000 Volume: 97 Issue: 26

Year: 2000 Volume: 97 Issue: 25

Year: 2000 Volume: 97 Issue: 24

Year: 2000 Volume: 97 Issue: 23

Year: 2000 Volume: 97 Issue: 22

Year: 2000 Volume: 97 Issue: 21

Year: 2000 Volume: 97 Issue: 20

Year: 2000 Volume: 97 Issue: 19

Year: 2000 Volume: 97 Issue: 18

Year: 2000 Volume: 97 Issue: 17

Year: 2000 Volume: 97 Issue: 16

Year: 2000 Volume: 97 Issue: 15

Year: 2000 Volume: 97 Issue: 14

Year: 2000 Volume: 97 Issue: 13

Year: 2000 Volume: 97 Issue: 12

Year: 2000 Volume: 97 Issue: 11

Year: 2000 Volume: 97 Issue: 10

5-Lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases

Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction.

Inhibition of calcium/calmodulin kinase II alpha subunit expression results in epileptiform activity in cultured hippocampal neurons.

In vitro evolution of a T cell receptor with high affinity for peptide/MHC.

Increased IGF-II protein affects p57kip2 expression in vivo and in vitro: implications for Beckwith-Wiedemann syndrome.

The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel

Xenopus kielin: A dorsalizing factor containing multiple chordin-type repeats secreted from the embryonic midline.

Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses.

Gain of imprinting at chromosome 11p15: A pathogenetic mechanism identified in human hepatocarcinomas.

Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction.

Uncompensated polyuria in a mouse model of Bartter's syndrome

An autologous oral DNA vaccine protects against murine melanoma.

Characterization of PDZ-binding kinase, a mitotic kinase.

The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae.

Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat.

Nuclear structure in normal and Bloom syndrome cells.

The fourth chromosome of Drosophila melanogaster: interspersed euchromatic and heterochromatic domains.

The phylogeny of closely related species as revealed by the genealogy of a speciation gene, Odysseus.

Early-life exposure to endotoxin alters hypothalamic-pituitary-adrenal function and predisposition to inflammation.

Growth of new brainstem connections in adult monkeys with massive sensory loss.

A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5.

5-methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex.

National security and scientific communication.

Critical contribution of liver natural killer T cells to a murine model of hepatitis.

Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide.

Peptide interfacial adsorption is kinetically limited by the thermodynamic stability of self association.

A highly digestible sorghum mutant cultivar exhibits a unique folded structure of endosperm protein bodies

Epithelial and endothelial expression of the green fluorescent protein reporter gene under the control of bovine prion protein (PrP) gene regulatory sequences in transgenic mice.

Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes.

Density-dependent decline of host abundance resulting from a new infectious disease.

The myosin motor, Myo4p, binds Ash1 mRNA via the adapter protein, She3p.

Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet.

The long-range supraorganization of the bacterial photosynthetic unit: A key role for PufX.

Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts.

Aberrant B cell receptor signaling from B29 (Igbeta, CD79b) gene mutations of chronic lymphocytic leukemia B cells.

Conversion of a c type cytochrome to a b type that spontaneously forms in vitro from apo protein and heme: implications for c type cytochrome biogenesis and folding.

Separation of the glucose-stimulated cytoplasmic and mitochondrial NAD(P)H responses in pancreatic islet beta cells.

Bepridil opens the regulatory N-terminal lobe of cardiac troponin C

Inverse radiation dose-rate effects on somatic and germ-line mutations and DNA damage rates.

Computation, prediction, and experimental tests of fitness for bacteriophage T7 mutants with permuted genomes.

Misactivated amino acids translocate at similar rates across surface of a tRNA synthetase.

Rapid transition in the structure of a coral reef community: the effects of coral bleaching and physical disturbance.

Single-molecule protein folding: diffusion fluorescence resonance energy transfer studies of the denaturation of chymotrypsin inhibitor 2.

Rapid regulated dense-core vesicle exocytosis requires the CAPS protein

Cyclin A activates the DNA polymerase delta -dependent elongation machinery in vitro: A parvovirus DNA replication model.

Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton.

Mapping the interface between calmodulin and MARCKS-related protein by fluorescence spectroscopy.

A universal scaling law between gray matter and white matter of cerebral cortex.

The tomato ethylene receptors NR and LeETR4 are negative regulators of ethylene response and exhibit functional compensation within a multigene family.

Estimating the probability for a protein to have a new fold: A statistical computational model.

The crystal structure of the Rev binding element of HIV-1 reveals novel base pairing and conformational variability.

Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human beta-globin in engrafted mice.

Establishment and persistence of photoperiodic memory in hamsters.

Deficits in memory and motor performance in synaptotagmin IV mutant mice.

Automated parallel DNA sequencing on multiple channel microchips.

Noise in neurons is message dependent.

A neuronal β subunit (KCNMB4) makes the large conductance, voltage- and $Ca^{2+}-activated$ $K^{+}$ channel resistant to charybdotoxin and iberiotoxin

Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF.

A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solution.

Sortase, a universal target for therapeutic agents against gram-positive bacteria?

Supramolecular complexes in photosynthetic bacteria.

Microcolumns in the cerebral cortex.

Gene therapy for the hemoglobin disorders: past, present, and future.

The making of infectious viral RNA: No size limit in sight.

Correlation between the structure of the bacterial peptidoglycan monomer unit, the specificity of transpeptidation, and susceptibility to beta-lactams.

Cell signaling pathways as control modules: complexity for simplicity?

Description of microcolumnar ensembles in association cortex and their disruption in Alzheimer and Lewy body dementias.

Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide.

Selective disruption of protein aggregation by cyclodextrin dimers.

New patterns of centrifugally driven thermal convection.

Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: implications for allosteric regulation.

Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.

DNA polymerase active site is highly mutable: evolutionary consequences.

Glutathione synthesis is essential for mouse development but not for cell growth in culture.

(4-Aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase

Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease.

Assembly of τ protein into Alzheimer paired helical filaments depends on a local sequence motif $(^{306}VQIVYK^{311})$ forming β structure

Direct nitric oxide signal transduction via nitrosylation of iron-sulfur centers in the SoxR transcription activator.

Noninvasive measurement of gene expression in skeletal muscle.

Detection and selective dissociation of intact ribosomes in a mass spectrometer.

A green fluorescent protein-reporter mammalian two-hybrid system with extrachromosomal maintenance of a prey expression plasmid: application to interaction screening.

Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells.

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding.

Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.

Sid4p is required to localize components of the septation initiation pathway to the spindle pole body in fission yeast.

Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa.

Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction.

Somatic polyploidization and cellular proliferation drive body size evolution in nematodes.

Novel gene conversion between X-Y homologues located in the nonrecombining region of the Y chromosome in Felidae (Mammalia).

Permanence or change? The meaning of genetic variation.

Rapid evolution in plant chitinases: molecular targets of selection in plant-pathogen coevolution.

An ancestral MADS-box gene duplication occurred before the divergence of plants and animals.

Gene content phylogeny of herpesviruses.

Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice

LexA chimeras reveal the function of Drosophila Fos as a context-dependent transcriptional activator.

Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity.

Rescue of dystrophin expression in mdx mouse muscle by RNA/DNA oligonucleotides.

Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy.

Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activity.

D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease.

Molecular basis for a link between complement and the vascular complications of diabetes.

AIS is an oncogene amplified in squamous cell carcinoma.

Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets.

Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice.

c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency.

Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections.

Engineering the largest RNA virus genome as an infectious bacterial artificial chromosome.

The Escherichia coli MG1655 in silico metabolic genotype: its definition, characteristics, and capabilities.

Production of infectious bovine papillomavirus from cloned viral DNA by using an organotypic raft/xenograft technique.

Neonatal lead exposure impairs development of rodent barrel field cortex.

A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse.

Coexistence of linear zones and pinwheels within orientation maps in cat visual cortex.

Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation.

Why are angles misperceived?

Acute decrease in net glutamate uptake during energy deprivation.

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids.

Postgerminative growth and lipid catabolism in oilseeds lacking the glyoxylate cycle.

Nas-Walras equilibria of a large economy.

Year: 2000 Volume: 97 Issue: 9

Year: 2000 Volume: 97 Issue: 8

Year: 2000 Volume: 97 Issue: 7

Year: 2000 Volume: 97 Issue: 6

Year: 2000 Volume: 97 Issue: 5

Year: 2000 Volume: 97 Issue: 4

Year: 2000 Volume: 97 Issue: 3

Year: 2000 Volume: 97 Issue: 2

Year: 2000 Volume: 97 Issue: 1

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Nuclear structure in normal and Bloom syndrome cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Marciniak, R. A. Yankiwski, V. Guarente, L. Neff, N. F.
Description	Author Affiliation: Yankiwski V ( Laboratory of Molecular Genetics, New York Blood Center, 310 East 67th Street, New York, NY 10021, USA.);
Abstract	Bloom syndrome (BS) is a rare cancer-predisposing disorder in which the cells of affected persons have a high frequency of somatic mutation and genomic instability. BLM, the protein altered in BS, is a RecQ DNA helicase. This report shows that BLM is found in the nucleus of normal human cells in the nuclear domain 10 or promyelocytic leukemia nuclear bodies. These structures are punctate depots of proteins disrupted upon viral infection and in certain human malignancies. BLM is found primarily in nuclear domain 10 except during S phase when it colocalizes with the Werner syndrome gene product, WRN, in the nucleolus. BLM colocalizes with a select subset of telomeres in normal cells and with large telomeric clusters seen in simian virus 40-transformed normal fibroblasts. During S phase, BS cells expel micronuclei containing sites of DNA synthesis. BLM is likely to be part of a DNA surveillance mechanism operating during S phase.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adenosine Triphosphatases Bloom Syndrome Pathology Cell Nucleus Ultrastructure DNA Helicases Adolescent Enzymology Genetics Cell Line Cell Nucleolus Child, Preschool Consanguinity Exodeoxyribonucleases Jews Pedigree Polymorphism, Restriction Fragment Length RecQ Helicases Reference Values S Phase Telomere Werner Syndrome Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in