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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tsukamoto, A. S. Uchida, N. Buck, D. W. Reitsma, M. J. Phan, T. V. He, D. Weissman, I. L. Masek, M. Gage, F. H. |
| Description | Author Affiliation: Uchida N ( StemCells, Inc., 525 Del Rey Avenue, Suite C, Sunnyvale, CA 94085); |
| Abstract | Stem cells, which are clonogenic cells with self-renewal and multilineage differentiation properties, have the potential to replace or repair damaged tissue. We have directly isolated clonogenic human central nervous system stem cells (hCNS-SC) from fresh human fetal brain tissue, using antibodies to cell surface markers and fluorescence-activated cell sorting. These hCNS-SC are phenotypically 5F3 (CD133)(+), 5E12(+), CD34(-), CD45(-), and CD24(-/lo). Single CD133(+) CD34(-) CD45(-) sorted cells initiated neurosphere cultures, and the progeny of clonogenic cells could differentiate into both neurons and glial cells. Single cells from neurosphere cultures initiated from CD133(+) CD34(-) CD45(-) cells were again replated as single cells and were able to reestablish neurosphere cultures, demonstrating the self-renewal potential of this highly enriched population. Upon transplantation into brains of immunodeficient neonatal mice, the sorted/expanded hCNS-SC showed potent engraftment, proliferation, migration, and neural differentiation. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 26 |
| Volume Number | 97 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2000-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Brain Cytology Central Nervous System Membrane Glycoproteins Spinal Cord Stem Cells Animals Antibodies, Monoclonal Immunology Antigens, CD Antigens, CD24 Antigens, CD34 Antigens, CD45 Biological Markers Embryology Metabolism Cell Differentiation Cell Separation Mice Mice, Inbred BALB C Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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