NDLI: Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice.

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Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice.

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Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Keller, Gordon Shpall, Elizabeth J. Hogan, Christopher J.
Description	Author Affiliation: Hogan CJ ( Bone Marrow Transplant Program, Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA. chris.hogan@uchsc.edu);
Abstract	Over the past decade xenotransplantation systems have been used with increasing success to gain a better understanding of human cells that are able to initiate and maintain the hematopoietic system in vivo. The nonobese diabetic/severe combined immunodeficiency (SCID) mouse has been a particularly useful model. Human cells capable of hematopoietic repopulation in this mouse, termed SCID-repopulating cells, have been assumed to represent the most primitive elements of the hematopoietic system, responsible for long-term maintenance of hematopoiesis. However, we demonstrate that SCID-repopulating cells present in the CD34(+) cell fraction of cord blood can be segregated into subpopulations with distinct repopulation characteristics. CD34(+)/CD38(+) progenitors can repopulate recipients rapidly, but can only maintain the graft for 12 weeks or less and have no secondary repopulation potential. Conversely, the more primitive CD34(+)/CD38(-) subpopulation repopulates recipients more gradually, can maintain the graft for at least 20 weeks, and contains cells with serial repopulation potential throughout the engraftment period. Additionally, a much higher frequency of T cell precursors are found among SCID-repopulating cells in the CD34(+)/CD38(-) subpopulation. These findings demonstrate that cells with variable repopulation potential comprise the human CD34(+) population and that short- and long-term potential of human precursors can be evaluated in the mouse model.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	1
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, CD34 Biosynthesis Antigens, CD Fetal Blood Cytology ADP-ribosyl Cyclase Animals Antigens, CD38 Antigens, CD45 Antigens, Differentiation Bone Marrow Cells Metabolism Cell Lineage Cell Separation Flow Cytometry Kinetics Membrane Glycoproteins Mice Mice, Inbred NOD Mice, SCID NAD+ Nucleosidase Protein Binding Subcellular Fractions Thymus Gland Time Factors Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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