NDLI: ATP-dependent structural change of the eukaryotic clamp-loader protein, replication factor C.

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ATP-dependent structural change of the eukaryotic clamp-loader protein, replication factor C.

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ATP-dependent structural change of the eukaryotic clamp-loader protein, replication factor C.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nakayama, Y. Tsurimoto, T. Usukura, J. Yoshikawa, H. Shiomi, Y. Obuse, C. Takeyasu, K. Masamura, Y.
Description	Author Affiliation: Shiomi Y ( Nara Institute of Science and Technology, Takayama, Ikoma, Nara 630-0101, Japan.);
Abstract	The eukaryotic DNA sliding clamp that keeps DNA polymerase engaged at a replication fork, called proliferating cell nuclear antigen (PCNA), is loaded onto the 3' ends of primer DNA through its interaction with a heteropentameric protein complex called replication factor C (RFC). The ATPase activity of RFC is necessary for formation of a functional PCNA clamp. In the present study, the sensitivity of RFC to partial proteolysis is used to show that addition of ATP, ATPgammaS, or ADP induces different structural changes in RFC. Direct observation by electron microscopy reveals that RFC has a closed two-finger structure called the U form in the absence of ATP. This is converted into a more open C form on addition of ATP. In contrast, the structural changes induced by ATPgammaS or ADP are limited. These results suggest that RFC adapts on opened configuration intermediately after ATP hydrolysis. We further observe that PCNA is held between the two fingers of RFC and propose that the RFC structure change we observe during ATP hydrolysis causes the attached PCNA to form its active ring-like clamp on DNA.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	26
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adenosine Triphosphate Metabolism DNA-Binding Proteins Chemistry Homeodomain Proteins Proliferating Cell Nuclear Antigen Proto-Oncogene Proteins C-bcl-2 Repressor Proteins Saccharomyces Cerevisiae Proteins Animals Binding Sites Cell Line Electrophoresis, Polyacrylamide Gel Eukaryotic Cells Microscopy, Atomic Force Microscopy, Electron Minor Histocompatibility Antigens Protein Conformation Replication Protein C Spodoptera Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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