NDLI: spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily.

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spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily.

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spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Greenwald, I. Levitan, D. Li, X. Wen, C.
Description	Author Affiliation: Wen C ( Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA.);
Abstract	Presenilin plays critical roles in the genesis of Alzheimer's disease and in LIN-12/Notch signaling during development. Here, we describe a screen for genes that influence presenilin level or activity in Caenorhabditis elegans. We identified four spr (suppressor of presenilin) genes by reverting the egg-laying defective phenotype caused by a null allele of the sel-12 presenilin gene. We analyzed the spr-2 gene in some detail. We show that loss of spr-2 activity suppresses the egg-laying defective phenotype of different sel-12 alleles and requires activity of the hop-1 presenilin gene, suggesting that suppression is accomplished by elevating presenilin activity rather than by bypassing the need for presenilin activity. We also show that SPR-2 is a nuclear protein and is a member of a protein subfamily that includes human SET, which has been identified in numerous different biochemical assays and at translocation breakpoints associated with a subtype of acute myeloid leukemia.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	26
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Caenorhabditis Elegans Proteins Helminth Proteins Genetics Metabolism Membrane Proteins Nuclear Proteins Oviposition Physiology Alleles Amino Acid Sequence Animals Animals, Genetically Modified Caenorhabditis Elegans Cell Nucleus Chromosomal Proteins, Non-Histone Cloning, Molecular DNA, Helminth Gene Expression Regulation Green Fluorescent Proteins Classification Histone Chaperones Luminescent Proteins Molecular Sequence Data Phenotype Proteins Transcription Factors Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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