NDLI: Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2001 Volume: 98 Issue: 26

Year: 2001 Volume: 98 Issue: 25

Year: 2001 Volume: 98 Issue: 24

Year: 2001 Volume: 98 Issue: 23

Year: 2001 Volume: 98 Issue: 22

Year: 2001 Volume: 98 Issue: 21

Year: 2001 Volume: 98 Issue: 20

Year: 2001 Volume: 98 Issue: 19

Year: 2001 Volume: 98 Issue: 18

Year: 2001 Volume: 98 Issue: 17

Year: 2001 Volume: 98 Issue: 16

Year: 2001 Volume: 98 Issue: 15

Year: 2001 Volume: 98 Issue: 14

Year: 2001 Volume: 98 Issue: 13

Year: 2001 Volume: 98 Issue: 12

Year: 2001 Volume: 98 Issue: 11

Year: 2001 Volume: 98 Issue: 10

Year: 2001 Volume: 98 Issue: 9

Year: 2001 Volume: 98 Issue: 8

Year: 2001 Volume: 98 Issue: 7

Year: 2001 Volume: 98 Issue: 6

Year: 2001 Volume: 98 Issue: 5

Year: 2001 Volume: 98 Issue: 4

Year: 2001 Volume: 98 Issue: 3

Order emerging from chaos in human evolutionary genetics.

DNA replication blockade impairs p53-transactivation.

Plant mitogen-activated protein kinase cascades: Negative regulatory roles turn out positive.

PDZ domains: More than just a glue.

Polycystic kidney disease: In danger of being X-rated?

How might cannabinoids influence sexual behavior?

A highly variable segment of human subterminal 16p reveals a history of population growth for modern humans outstide Africa.

State-of-the-art instruments for detecting extraterrestrial life.

Possible ecosystems and the search for life on Europa.

The universal nature of biochemistry.

The occurrence of Jovian planets and the habitability of planetary systems.

Self-assembling amphiphilic molecules: Synthesis in simulated interstellar/precometary ices.

Differential adsorption of nucleic acid bases: Relevance to the origin of life.

In situ laser-Raman imagery of precambrian microscopic fossils.

Pre-global surveyor evidence for Martian ground water.

Evolution of treatment effects over time: empirical insight from recursive cumulative metaanalyses.

A stochastic model for the self-similar heterogeneity of regional organ blood flow.

AB-polymer networks based on oligo(epsilon-caprolactone) segments showing shape-memory properties.

Convex Arrhenius plots and their interpretation.

Monolayers of derivatized poly(L-lysine)-grafted poly(ethylene glycol) on metal oxides as a class of biomolecular interfaces.

Distinctive genetic signatures in the Libyan Jews.

De novo design and characterization of an apolar helical hairpin peptide at atomic resolution: Compaction mediated by weak interactions.

Overexpression of the inositol phosphatase SopB in human 293 cells stimulates cellular chloride influx and inhibits nuclear mRNA export.

Polar side chains drive the association of model transmembrane peptides.

Ribosome shunt is essential for infectivity of cauliflower mosaic virus.

Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly.

Rotation of the c subunit oligomer in fully functional $F_{1}F_{o}$ ATP synthase

Directed evolution of ampicillin-resistant activity from a functionally unrelated DNA fragment: A laboratory model of molecular evolution.

The critical role of DNA in the equilibrium between OmpR and phosphorylated OmpR mediated by EnvZ in Escherichia coli.

Subunit interactions influence the biochemical and biological properties of Hsp104.

Protein-protein interactions with subunits of human nuclear RNase P.

Characterization of a quinone reductase activity for the mitomycin C binding protein (MRD): Functional switching from a drug-activating enzyme to a drug-binding protein.

An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190.

Caspase-2 pre-mRNA alternative splicing: Identification of an intronic element containing a decoy 3' acceptor site.

Molecular clocks.

Selectin receptor-ligand bonds: Formation limited by shear rate and dissociation governed by the Bell model.

Changes in protein conformational mobility upon activation of extracellular regulated protein kinase-2 as detected by hydrogen exchange.

Primary reactions of sensory rhodopsins.

Dynamics of site juxtaposition in supercoiled DNA.

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase.

The MinE ring required for proper placement of the division site is a mobile structure that changes its cellular location during the Escherichia coli division cycle.

Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene.

Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program.

Aquaporins in Saccharomyces: Characterization of a second functional water channel protein.

The midblastula transition in Xenopus embryos activates multiple pathways to prevent apoptosis in response to DNA damage.

Proteins associated with the promyelocytic leukemia gene product (PML)-containing nuclear body move to the nucleolus upon inhibition of proteasome-dependent protein degradation.

Characterization of Rny1, the Saccharomyces cerevisiae member of the T2 RNase family of RNases: unexpected functions for ancient enzymes?

Interaction of endostatin with integrins implicated in angiogenesis.

REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus.

p53 accumulates but is functionally impaired when DNA synthesis is blocked.

Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands.

Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors.

Expression pattern of Drosophila ret suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neurons.

Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2.

PDX:PBX complexes are required for normal proliferation of pancreatic cells during development.

Fertile and diploid nuclear transplants derived from embryonic cells of a small laboratory fish, medaka (Oryzias latipes)

Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle.

Extrafloral nectar production of the ant-associated plant, Macaranga tanarius, is an induced, indirect, defensive response elicited by jasmonic acid.

To walk or to fly? How birds choose among foraging modes.

Patterns of spread in biological invasions dominated by long-distance jump dispersal: Insights from Argentine ants.

An orphaned mammalian beta-globin gene of ancient evolutionary origin.

Environmental stress and mutational load in diploid strains of the yeast Saccharomyces cerevisiae.

Fitness effects of advantageous mutations in evolving Escherichia coli populations.

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors.

Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics.

Analysis of the blind Drosophila mutant ninaB identifies the gene encoding the key enzyme for vitamin A formation invivo.

Similar regions of human chromosome 3 are eliminated from or retained in human/human and human/mouse microcell hybrids during tumor growth in severe combined immunodeficient (SCID) mice

Genetic remodeling of protein glycosylation in vivo induces autoimmune disease.

The mechanism by which a peptide based on complementarity-determining region-1 of a pathogenic anti-DNA auto-Ab ameliorates experimental systemic lupus erythematosus.

Activated Cdc42/Rac reconstitutes FcɛRI-mediated $Ca^{2+}$ mobilization and degranulation in mutant RBL mast cells

CD8+ T cells recognize an inclusion membrane-associated protein from the vacuolar pathogen Chlamydia trachomatis.

CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans.

A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys.

Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer.

Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1.

Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice.

Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini.

Copper-64-diacetyl-bis(N4-methylthiosemicarbazone): An agent for radiotherapy.

Prolonging the half-life of human interferon-alpha 2 in circulation: Design, preparation, and analysis of (2-sulfo-9-fluorenylmethoxycarbonyl)7- interferon-alpha 2.

Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells.

An Epstein-Barr-related herpesvirus from marmoset lymphomas.

Odor-evoked calcium signals in dendrites of rat mitral cells.

Nodes of Ranvier form in association with ezrin-radixin-moesin (ERM)-positive Schwann cell processes.

Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method.

Progesterone receptor and dopamine receptors are required in $Δ^{9}-tetrahydrocannabinol$ modulation of sexual receptivity in female rats

Dopamine-dependent synaptic plasticity in striatum during in vivo development.

Contribution of cytoskeleton to the internalization of AMPA receptors.

Cholesterol binding at the cholesterol recognition/ interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide.

Control of eye movements and spatial attention.

Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase.

What is a moment? Transient synchrony as a collective mechanism for spatiotemporal integration.

Expression of Q227L-Galpha(s) inhibits intimal vessel wall hyperplasia after balloon injury.

Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice.

Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction.

Parthenocarpic apple fruit production conferred by transposon insertion mutations in a MADS-box transcription factor.

N-cadherin is regulated by gonadal steroids in the adult hippocampus.

Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel.

Year: 2001 Volume: 98 Issue: 2

Year: 2001 Volume: 98 Issue: 1

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mak, D. O. Foskett, J. K. Raghuram, V.
Description	Author Affiliation: Raghuram V ( Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104-6100, USA.);
Abstract	The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent protein kinase- and ATP-regulated chloride channel, the activity of which determines the rate of electrolyte and fluid transport in a variety of epithelial tissues. Here we describe a mechanism that regulates CFTR channel activity, which is mediated by PDZ domains, a family of conserved protein-interaction modules. The Na(+)/H(+) exchanger regulatory factor (NHERF) binds to the cytoplasmic tail of CFTR through either of its two PDZ (PDZ1 and PDZ2) domains. A recombinant fragment of NHERF (PDZ1-2) containing the two PDZ domains increases the open probability (P(o)) of single CFTR channels in excised membrane patches from a lung submucosal gland cell line. Both PDZ domains are required for this functional effect, because peptides containing mutations in either domain are unable to increase channel P(o). The concentration dependence of the regulation by the bivalent PDZ1-2 domain is biphasic, i.e., activating at lower concentrations and inhibiting at higher concentrations. Furthermore, either PDZ domain alone or together is without effect on P(o), but either domain can competitively inhibit the PDZ1-2-mediated stimulation of CFTR. Our results support a molecular model in which bivalent NHERF PDZ domains regulate channel gating by crosslinking the C-terminal tails in a single dimeric CFTR channel, and the magnitude of this regulation is coupled to the stoichiometry of these interactions.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cystic Fibrosis Transmembrane Conductance Regulator Chemistry Physiology Amino Acid Sequence Animals Binding Sites CHO Cells Cell Membrane Conserved Sequence Cricetinae Genetics Ion Channel Gating Kinetics Lung Membrane Potentials Molecular Sequence Data Peptide Fragments Metabolism Recombinant Fusion Proteins Respiratory Mucosa Transfection Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in