NDLI: Differential adsorption of nucleic acid bases: Relevance to the origin of life.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cohn, C. A. Sowerby, S. J. Heckl, W. M. Holm, N. G.
Description	Author Affiliation: Sowerby SJ ( Department of Geology and Geochemistry, Stockholm University, SE-106 91 Stockholm, Sweden.);
Abstract	The adsorption of organic molecules onto the surfaces of inorganic solids has long been considered a process relevant to the origin of life. We have determined the equilibrium adsorption isotherms for the nucleic acid purine and pyrimidine bases dissolved in water on the surface of crystalline graphite. The markedly different adsorption behavior of the bases describes an elutropic series: guanine > adenine > hypoxanthine > thymine > cytosine > uracil. We propose that such differential properties were relevant to the prebiotic chemistry of the bases and may have influenced the composition of the primordial genetic architecture.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Origin Of Life Purines Chemistry Pyrimidines Adenine Adsorption Cytosine Guanine Hypoxanthine RNA Genetics Surface Properties Thymine Uracil Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Differential adsorption of nucleic acid bases: Relevance to the origin of life.