NDLI: An orphaned mammalian beta-globin gene of ancient evolutionary origin.

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An orphaned mammalian beta-globin gene of ancient evolutionary origin.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bottema, C. D. Webb, G. C. Gooley, A. A. Cooper, S. B. Goodman, M. Hope, R. Dolman, G. Holland, R. A. Wheeler, D.
Description	Author Affiliation: Wheeler D ( Laboratory of Molecular Evolution, Department of Molecular Biosciences, Adelaide University, South Australia 5005, Australia.);
Abstract	Mammals possess multiple, closely linked beta-globin genes that differ in the timing of their expression during development. These genes have been thought to be derived from a single ancestral gene, by duplication events that occurred after the separation of the mammals and birds. We report the isolation and characterization of an atypical beta-like globin gene (omega-globin) in marsupials that appears to be more closely related to avian beta-globin genes than to other mammalian beta-globin genes, including those previously identified in marsupials. Phylogenetic analyses indicate that omega-globin evolved from an ancient gene duplication event that occurred before the divergence of mammals and birds. Furthermore, we show that omega-globin is unlinked to the previously characterized beta-globin gene cluster of marsupials, making this the first report of an orphaned beta-like globin gene expressed in a vertebrate.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Evolution, Molecular Globins Genetics Mammals Classification Marsupialia Phylogeny Amino Acid Sequence Animals Cloning, Molecular Gene Duplication Chemistry Molecular Sequence Data Polymerase Chain Reaction Sequence Alignment Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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