NDLI: Spontaneous retinopathy in HLA-A29 transgenic mice.

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Spontaneous retinopathy in HLA-A29 transgenic mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chopin, M. Dausset, J. Pla, M. De Kozak, Y. Vieville, J. C. Edelson, C. Naud, M. C. Szpak, Y. Tabary, T. Cohen, J. H.
Description	Author Affiliation: Szpak Y ( Mouse Immunogenetics, Institut National de la Santé et de la Recherche Médicale, Unité 462, Institute of Hematology, Saint-Louis Hospital, 1 Avenue Claude Vellefaux, 75475 Paris Cedex 10, France.);
Abstract	Humans who have inherited the class I major histocompatibility allele HLA-A29 have a markedly increased relative risk of developing the eye disease termed birdshot chorioretinopathy. This disease affecting adults is characterized by symmetrically scattered, small, cream-colored spots in the fundus associated with retinal vasculopathy and inflammatory signs causing damage to the ocular structures, leading regularly to visual loss. To investigate the role of HLA-A29 in this disease, we introduced the HLA-A29 gene into mice. Aging HLA-A29 transgenic mice spontaneously developed retinopathy, showing a striking resemblance to the HLA-A29-associated chorioretinopathy. These results strongly suggest that HLA-A29 is involved in the pathogenesis of this disease. Elucidation of the role of HLA-A29 should be assisted by this transgenic model.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	HLA-A Antigens Physiology Retinal Diseases Immunology Animals Flow Cytometry Genetics Mice Mice, Inbred BALB C Mice, Transgenic Pathology Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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