NDLI: Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2003 Volume: 100 Issue: 26

Year: 2003 Volume: 100 Issue: 25

Year: 2003 Volume: 100 Issue: 24

Year: 2003 Volume: 100 Issue: 23

Year: 2003 Volume: 100 Issue: 22

Year: 2003 Volume: 100 Issue: 21

Year: 2003 Volume: 100 Issue: 20

Year: 2003 Volume: 100 Issue: 19

Year: 2003 Volume: 100 Issue: 18

Year: 2003 Volume: 100 Issue: 17

Year: 2003 Volume: 100 Issue: 16

Year: 2003 Volume: 100 Issue: 15

Year: 2003 Volume: 100 Issue: 14

Year: 2003 Volume: 100 Issue: 13

Year: 2003 Volume: 100 Issue: 12

Year: 2003 Volume: 100 Issue: 11

Sexual transmission of the [Het-S] prion leads to meiotic drive in Podospora anserina.

Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice.

Genomewide view of gene silencing by small interfering RNAs.

Alcohol potently inhibits the kainate receptor-dependent excitatory drive of hippocampal interneurons.

Sympatric speciation as a consequence of male pregnancy in seahorses.

Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways.

Antagonistic control of oxidative stress-induced cell death in Arabidopsis by two related, plant-specific zinc finger proteins.

Guanylate cyclase-activating protein (GCAP) 1 rescues cone recovery kinetics in GCAP1/GCAP2 knockout mice

Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice.

Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization.

Differential expression of growth factors at the cellular level in virus-infected brain

Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis.

Picosecond conformational transition and equilibration of a cyclic peptide.

Two Arabidopsis circadian oscillators can be distinguished by differential temperature sensitivity.

Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero.

Interaction of antimicrobial peptide protegrin with biomembranes.

TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution.

The putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of carbon and nitrogen metabolism in Arabidopsis thaliana

T lymphoid differentiation in human bone marrow.

Compression forces generated by actin comet tails on lipid vesicles.

Coincidence of synteny breakpoints with malignancy-related deletions on human chromosome 3.

Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7.

Exo1: a new chemical inhibitor of the exocytic pathway.

Spermatogonial stem cells share some, but not all, phenotypic and functional characteristics with other stem cells.

Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5.

Identification of receptors for pig endogenous retrovirus.

Development of teeth in chick embryos after mouse neural crest transplantations.

T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions.

Purine synthesis and increased Agrobacterium tumefaciens transformation of yeast and plants.

Understanding tubulin-Taxol interactions: mutations that impart Taxol binding to yeast tubulin.

A fragment of anthrax lethal factor delivers proteins to the cytosol without requiring protective antigen.

Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants.

Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.

Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange.

Control of seed germination in transgenic plants based on the segregation of a two-component genetic system.

PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages.

Susceptibility to tuberculosis: A locus on mouse chromosome 19 (Trl-4) regulates Mycobacterium tuberculosis replication in the lungs

Retrofitting existing chemical scrubbers to biotrickling filters for $H_{2}S$ emission control

Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis.

Quality control of ribosomal RNA mediated by polynucleotide phosphorylase and RNase R.

Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia.

Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors

An actin-ribonucleoprotein interaction is involved in transcription by RNA polymerase II.

A dual altered peptide ligand down-regulates myasthenogenic T cell responses by up-regulating CD25- and CTLA-4-expressing CD4+ T cells.

Direct stimulation of naive T cells by membrane vesicles from antigen-presenting cells: distinct roles for CD54 and B7 molecules.

Golgi-dependent transport of cholesterol to the Chlamydia trachomatis inclusion.

Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila.

ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays.

Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B protein.

Evidence for a genetic discontinuity between Neandertals and 24,000-year-old anatomically modern Europeans.

Exponential growth by cross-catalytic cleavage of deoxyribozymogens.

Biocomplexity and fisheries sustainability.

Inhibition of p53-induced apoptosis without affecting expression of p53-regulated genes.

The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation.

Spectra of random graphs with given expected degrees.

Tracing the origin and history of the HIV-2 epidemic.

Mate choice theory and the mode of selection in sexual populations.

Molecular paleontology of transposable elements in the Drosophila melanogaster genome.

Structural defects and the diagnosis of amyloidogenic propensity.

Functional divergence within the APETALA3/PISTILLATA floral homeotic gene lineages.

Global atmospheric black carbon inferred from AERONET.

Interaction of soft condensed materials with living cells: phenotype/transcriptome correlations for the hydrophobic effect.

Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo.

Chloride, not sodium, stimulates expression of the γ subunit of Na/K-ATPase and activates JNK in response to hypertonicity in mouse IMCD3 cells

Specificity of short interfering RNA determined through gene expression signatures.

Myocardial recovery from ischemia is impaired in CD36-null mice and restored by myocyte CD36 expression or medium-chain fatty acids.

Beta3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice.

Vam10p defines a Sec18p-independent step of priming that allows yeast vacuole tethering.

Trehalose 6-phosphate is indispensable for carbohydrate utilization and growth in Arabidopsis thaliana.

Immunization with hepatitis C virus-like particles protects mice from recombinant hepatitis C virus-vaccinia infection.

Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function.

Short- and long-term enhancement of excitatory transmission in the spinal cord dorsal horn by nicotinic acetylcholine receptors.

Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs.

An EP2 receptor-selective prostaglandin E2 agonist induces bone healing.

Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana.

Dictyostelium and Acanthamoeba myosin II assembly domains go to the cleavage furrow of Dictyostelium myosin II-null cells.

Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance.

Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation.

The receptor kinases LePRK1 and LePRK2 associate in pollen and when expressed in yeast, but dissociate in the presence of style extract.

Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta.

D-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors.

Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability.

Spontaneous mitotic homologous recombination at an enhanced yellow fluorescent protein (EYFP) cDNA direct repeat in transgenic mice.

The working stroke upon myosin-nucleotide complexes binding to actin.

Evolution of the army ant syndrome: the origin and long-term evolutionary stasis of a complex of behavioral and reproductive adaptations.

Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.

Conservation and molecular dissection of ROUGH SHEATH2 and ASYMMETRIC LEAVES1 function in leaf development.

Structure of the coat protein in fd filamentous bacteriophage particles determined by solid-state NMR spectroscopy.

Beyond superquenching: hyper-efficient energy transfer from conjugated polymers to gold nanoparticles.

Genomewide demarcation of RNA polymerase II transcription units revealed by physical fractionation of chromatin.

Beta cell MHC class I is a late requirement for diabetes.

How the BfiI restriction enzyme uses one active site to cut two DNA strands.

Global perception in small brains: topological pattern recognition in honey bees.

sal1 determines the number of aleurone cell layers in maize endosperm and encodes a class E vacuolar sorting protein.

A new Drosophila spliceosomal intron position is common in plants.

Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor.

Adrenergic regulation of clock gene expression in mouse liver.

Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase.

Programming peptidomimetic syntheses by translating genetic codes designed de novo.

The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription.

Copper chelation represses the vascular response to injury

The specifics of small interfering RNA specificity.

A fratricidal fungal prion.

Suppression of macrophage inflammatory responses by PPARs.

Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice.

Year: 2003 Volume: 100 Issue: 10

Year: 2003 Volume: 100 Issue: 9

Year: 2003 Volume: 100 Issue: 8

Year: 2003 Volume: 100 Issue: 7

Year: 2003 Volume: 100 Issue: 6

Year: 2003 Volume: 100 Issue: 5

Year: 2003 Volume: 100 Issue: 4

Year: 2003 Volume: 100 Issue: 3

Year: 2003 Volume: 100 Issue: 2

Year: 2003 Volume: 100 Issue: Suppl 2

Year: 2003 Volume: 100 Issue: 1

Year: 2003 Volume: 100 Issue: Suppl 1

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Howard, Timothy D. Delong, Cynthia J. Miller, Mark S. Weir, Holly M. Willingham, Mark C. Hicks, Amy M. Hawkins, Gregory A. Cui, Zheng Alexander-miller, Martha A. Du, Wei
Description	Author Affiliation: Cui Z ( Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. zhengcui@wfubmc.edu);
Abstract	We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is age-dependent spontaneous regression of advanced cancers. This powerful resistance segregates as a single-locus dominant trait, is independent of tumor burden, and is effective against cell lines from multiple types of cancer. During spontaneous regression or immediately after exposure, cancer cells provoke a massive infiltration of host leukocytes, which form aggregates and rosettes with tumor cells. The cytolytic destruction of cancer cells by innate leukocytes is rapid and specific without apparent damage to normal cells. The mice are healthy and cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance, which may have potential for therapy or prevention of cancer.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aging Genetics Neoplasm Regression, Spontaneous Neoplasms, Experimental Pathology Animals Flow Cytometry Mice Mice, Inbred BALB C Mice, Inbred C57BL Microscopy, Electron, Scanning Phenotype Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in