NDLI: ANX7, a candidate tumor suppressor gene for prostate cancer.

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ANX7, a candidate tumor suppressor gene for prostate cancer.

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ANX7, a candidate tumor suppressor gene for prostate cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Koivisto, P. Srivastava, S. Bubendorf, L. Raffeld, M. Kononen, J. Fehrle, W. Nolan, L. Srivastava, M. Fossom, L. Willi, N. Pittaluga, S. Kallioniemi, O. P. Leighton, X. Glasman, M. Pollard, H. B. Sauter, G. Srikantan, V. Gasser, T. C.
Description	Author Affiliation: Srivastava M ( Departments of Anatomy, Physiology, and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, MD 20814, USA. msrivastava@usuhs.mil);
Abstract	The ANX7 gene is located on human chromosome 10q21, a site long hypothesized to harbor a tumor suppressor gene(s) (TSG) associated with prostate and other cancers. To test whether ANX7 might be a candidate TSG, we examined the ANX7-dependent suppression of human tumor cell growth, stage-specific ANX7 expression in 301 prostate specimens on a prostate tissue microarray, and loss of heterozygosity (LOH) of microsatellite markers at or near the ANX7 locus. Here we report that human tumor cell proliferation and colony formation are markedly reduced when the wild-type ANX7 gene is transfected into two prostate tumor cell lines, LNCaP and DU145. Consistently, analysis of ANX7 protein expression in human prostate tumor microarrays reveals a significantly higher rate of loss of ANX7 expression in metastatic and local recurrences of hormone refractory prostate cancer as compared with primary tumors (P = 0.0001). Using four microsatellite markers at or near the ANX7 locus, and laser capture microdissected tumor cells, 35% of the 20 primary prostate tumors show LOH. The microsatellite marker closest to the ANX7 locus showed the highest rate of LOH, including one homozygous deletion. We conclude that the ANX7 gene exhibits many biological and genetic properties expected of a TSG and may play a role in prostate cancer progression.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Annexin A7 Genetics Genes, Tumor Suppressor Prostatic Neoplasms Cell Division Chromosomes, Human, Pair 10 Genetic Markers Immunohistochemistry Loss Of Heterozygosity Oligonucleotide Array Sequence Analysis Polymerase Chain Reaction Polymorphism, Genetic Pathology Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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