NDLI: Tissue spreading on implantable substrates is a competitive outcome of cell-cell vs. cell-substratum adhesivity.

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Tissue spreading on implantable substrates is a competitive outcome of cell-cell vs. cell-substratum adhesivity.

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Tissue spreading on implantable substrates is a competitive outcome of cell-cell vs. cell-substratum adhesivity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Foty, R. A. Kohn, J. Ryan, P. L. Steinberg, M. S.
Description	Author Affiliation: Ryan PL ( Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.);
Abstract	While the interactions of cells with polymeric substrata are widely studied, the influence of cell-cell cohesiveness on tissue spreading has not been rigorously investigated. Here we demonstrate that the rate of tissue spreading over a two-dimensional substratum reflects a competition or 'tug-of-war' between cell-cell and cell-substratum adhesions. We have generated both a 'library' of structurally related copolymeric substrata varying in their adhesivity to cells and a library of genetically engineered cell populations varying only in cohesiveness. Cell-substratum adhesivity was varied through the poly(ethylene glycol) content of a series of copolymeric substrata, whereas cell-cell cohesiveness was varied through the expression of the homophilic cohesion molecules N- and R-cadherin by otherwise noncohesive L929 cells. In the key experiment, multicellular aggregates containing about 600 cells were allowed to spread onto copolymeric surfaces. We compared the spreading behavior of aggregates having different levels of cell-cell cohesiveness in a series of copolymeric substrata having different levels of cell-substratum adhesivity. In these experiments, cell-cell cohesiveness was measured by tissue surface tensiometry, and cell-substratum adhesivity was assessed by a distractive method. Tissue spreading was assayed by confocal microscopy as the rate of cell emigration from similar-sized, fluorescence-labeled, multicellular aggregates deposited on each of the substrata. We demonstrate that either decreasing substratum adhesivity or increasing cell-cell cohesiveness dramatically slowed the spreading rate of cell aggregates.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Adhesion Cell Movement Animals Cell Line Mice Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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