NDLI: The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene.

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The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene.

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The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Himelstein, Andrew L. Negrini, Massimo Cesari, Rossano Martin, S. Eric Croce, Carlo M. Martin, Eric S. Pentimalli, Francesca Fishel, Richard Godwin, Andrew K. Yoder, Kristine
Description	Author Affiliation: Martin ES ( Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.);
Abstract	Frequent allelic loss at human chromosome 11q23-q24 occurs in a wide variety of cancers, suggesting that this region may harbor a tumor suppressor gene. By constructing a physical map of the LOH11CR2 minimal region of loss on 11q23-q24 associated with lung and breast carcinomas, we were able to clone a hereditary translocation, t(11;12)(q23;q24), in a patient with early-onset breast cancer and family history of cancer. The breakpoint was found within 6 kb of the BCSC-1 candidate tumor suppressor gene located in the LOH11CR2 region whereas additional loss of heterozygosity (LOH) analysis in breast and ovarian tumors, including that of the patient with the t(11;12)(q23;q24), implicated the BCSC-1 locus as the primary target of deletion. Northern analysis of the BCSC-1 mRNA revealed a lack of expression in 33 of 41 (80%) tumor cell lines, and its ectopic expression led to the suppression of colony formation in vitro and tumorigenicity in vivo. These data suggest that BCSC-1 may exert a tumor suppressor activity and is a likely target of the LOH observed on 11q23-q24 in cancer.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	20
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Chromosomes, Human, Pair 11 Genes, Tumor Suppressor Animals Chromosomes, Human, Pair 12 Karyotyping Loss Of Heterozygosity Mice Mice, Nude Molecular Sequence Data Mutation Pedigree Translocation, Genetic Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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