NDLI: Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia.

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Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia.

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Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hatsell, Sarah J. Rowlands, Tracey M. Pestell, Richard G. Cowin, Pamela Pechenkina, Irina V.
Description	Author Affiliation: Rowlands TM ( Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.);
Abstract	A considerable body of circumstantial data suggests that cyclin D1 is an attractive candidate to mediate the effects of beta-catenin in mammary tissue. To test the functional significance of these correlative findings, we investigated the genetic interaction between transcriptionally active beta-catenin (DeltaN89beta-catenin) and its target gene cyclin D1 in the mouse mammary gland during pubertal development, pregnancy, and tumorigenesis. Our data demonstrate that cyclin D1 is dispensable for the DeltaN89beta-catenin-stimulated initiation of alveologenesis in virgin females, for the de novo induction of alveoli in males, and for the formation of tumors. Indeed, lack of cyclin D1 accentuates and enhances these hyperplastic and tumorigenic DeltaN89beta-catenin phenotypes. Although alveologenesis is initiated by DeltaN89beta-catenin in a cyclin D1-independent fashion, up-regulation of cyclin D1 occurs in DeltaN89beta-catenin mice and its expression remains essential for the completion of alveolar development during the later stages of pregnancy. Thus, alveologenesis is a two-step process, and cyclin D1 activity during late alveologenesis cannot be replaced by the activity of other beta-catenin target genes that successfully drive proliferation at earlier stages.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	20
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cyclin D1 Physiology Cytoskeletal Proteins Mammary Glands, Animal Growth & Development Mammary Neoplasms, Experimental Pathology Trans-Activators Animals Mice Mice, Transgenic Pregnancy Beta Catenin Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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