NDLI: Expression of T cell receptor beta locus in central nervous system neurons.

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Expression of T cell receptor beta locus in central nervous system neurons.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Syken, Josh Shatz, Carla J.
Description	Author Affiliation: Syken J ( Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.);
Abstract	MHC class I proteins are cell-surface ligands that bind to T cell receptors and other immunoreceptors and act to regulate the activation state of immune cells. Recent work has shown that MHC class I genes and CD3zeta, an obligate component of T cell receptors, are expressed in neurons, are regulated by neuronal activity, and function in neuronal development and plasticity. A search for additional neuronally expressed T cell receptor components has revealed that the T cell antigen receptor beta (TCRbeta) locus is expressed in neurons of the murine central nervous system and that this expression is dynamically regulated over development. In neonates, expression is most abundant in various thalamic nuclei. At later ages and in adults, thalamic expression fades and cortical expression is robust, particularly in layer 6. In T cells, protein-encoding transcripts are produced only after recombination of the TCRbeta genomic locus, which joins variable, diversity, and joining regions, a process that creates much of the diversity of the immune system. We detect no genomic recombination in neurons. Rather, transcripts begin in regions upstream of several joining regions, and are spliced to constant region segments. One of the transcripts encodes a hypothetical 207-aa, 23-kDa protein, which includes the TCRbeta J2.7 region, and the entire C region. These observations suggest that TCRbeta may function in neurons.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Brain Immunology Gene Expression Regulation Genes, T-Cell Receptor Beta Genetics Neurons Amino Acid Sequence Animals Blotting, Northern Cerebellum Cerebral Cortex Chromosome Mapping DNA Primers Histocompatibility Antigens Class I Mice Mice, Inbred C57BL Molecular Sequence Data Polymerase Chain Reaction RNA, Messenger Receptors, Antigen, T-Cell, Alpha-beta Spleen Thalamus Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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