NDLI: Twin concordance and sibling recurrence rates in multiple sclerosis.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2003 Volume: 100 Issue: 26

Year: 2003 Volume: 100 Issue: 25

Year: 2003 Volume: 100 Issue: 24

Year: 2003 Volume: 100 Issue: 23

Year: 2003 Volume: 100 Issue: 22

Revealing the hidden atom in graphite by low-temperature atomic force microscopy.

Bias and error in estimates of equilibrium free-energy differences from nonequilibrium measurements.

Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis.

The energetic cost of domain reorientation in maltose-binding protein as studied by NMR and fluorescence spectroscopy.

Hypothalamic malonyl-CoA as a mediator of feeding behavior.

mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo.

Cyclothiazide potently inhibits gamma-aminobutyric acid type A receptors in addition to enhancing glutamate responses.

An endogenous retroviral long terminal repeat is the dominant promoter for human beta1,3-galactosyltransferase 5 in the colon.

Olivo-cerebellar cluster-based universal control system.

Branched aliphatic alkanes with quaternary substituted carbon atoms in modern and ancient geologic samples.

Developmental amnesia and its relationship to degree of hippocampal atrophy.

Processive phosphorylation of alternative splicing factor/splicing factor 2.

Differential regulation of symmetry genes and the evolution of floral morphologies.

A genetic lesion that arrests plasma cell homing to the bone marrow.

Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin.

Trace but not delay fear conditioning requires attention and the anterior cingulate cortex.

Synchronous coadaptation in an ancient case of herbivory.

Multiple, recurring origins of aposematism and diet specialization in poison frogs.

Evolution of eusociality and the soldier caste in termites: influence of intraspecific competition and accelerated inheritance.

AIPL1, a protein implicated in Leber's congenital amaurosis, interacts with and aids in processing of farnesylated proteins.

Fitness consequences of a regulatory polymorphism in a seasonal environment.

Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation.

Treatment of Helicobacter gastritis with IL-4 requires somatostatin.

Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system.

Evolution of the yeast protein interaction network.

A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.

Elevated gene expression levels distinguish human from non-human primate brains.

HIV-1 in genital tract and plasma of women: compartmentalization of viral sequences, coreceptor usage, and glycosylation.

Coloration strategies in peacock feathers.

Worker policing without genetic conflicts in a clonal ant.

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

Brain-derived neurotrophic factor-dependent unmasking of 'silent' synapses in the developing mouse barrel cortex.

Combinatorial discovery of two-photon photoremovable protecting groups.

Contrasting patterns of expression of transcription factors in pancreatic alpha and beta cells.

MADS box genes control vernalization-induced flowering in cereals.

DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a.

Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a.

Capture of an intermediate in the catalytic cycle of L-aspartate-beta-semialdehyde dehydrogenase.

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a

Adaptive mutation: general mutagenesis is not a programmed response to stress but results from rare coamplification of dinB with lac.

Glia-independent chains of neuroblasts through the subcortical parenchyma of the adult rabbit brain.

DNA-mediated charge transport for DNA repair.

Energetics of hydrogen bonds in peptides.

Principles of cell-free genetic circuit assembly.

RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells.

The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia.

Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds.

A modulatory role for facial expressions in prosopagnosia.

Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens.

Alu elements and hominid phylogenetics.

Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis.

Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy.

Transabdominal near infrared oximetry of hypoxic stress in fetal sheep brain in utero.

Localization and roles of Ski8p protein in Sordaria meiosis and delineation of three mechanistically distinct steps of meiotic homolog juxtaposition.

Eradication of pathogenic beta-catenin by Skp1/Cullin/F box ubiquitination machinery.

Damped elastic recoil of the titin spring in myofibrils of human myocardium.

The small RING finger protein Z drives arenavirus budding: implications for antiviral strategies.

Ancient maize from Chacoan great houses: where was it grown?

The detection and quantitation of free desmosine and isodesmosine in human urine and their peptide-bound forms in sputum.

The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss.

Helical Lévy walks: adjusting searching statistics to resource availability in microzooplankton.

Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit.

Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer.

Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome

Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins.

Nitric oxide-donating aspirin inhibits beta-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear beta-catenin-TCF association.

Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age.

Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation.

Proteorhodopsin genes are distributed among divergent marine bacterial taxa.

Predicting protein functions from redundancies in large-scale protein interaction networks.

A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2.

Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor.

Probable extirpation of a breeding colony of Short-tailed Albatross (Phoebastria albatrus) on Bermuda by Pleistocene sea-level rise.

Exploiting luminescence spectroscopy to elucidate the interaction between sugar and a tryptophan residue in the lactose permease of Escherichia coli.

The genome of Nanoarchaeum equitans: insights into early archaeal evolution and derived parasitism.

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis.

Evolutionary specialization of a tryptophan indole group for transition-state stabilization by eukaryotic transglutaminases

Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture.

A plant virus replication system to assay the formation of RNA pseudotriloop motifs in RNA-protein interactions.

Dynamic structures in Escherichia coli: spontaneous formation of MinE rings and MinD polar zones.

Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies.

Identification of T cell-signaling pathways that stimulate latent HIV in primary cells.

Biodiversity as spatial insurance in heterogeneous landscapes.

Induction of crossreactive antibodies against the Plasmodium falciparum variant protein.

Elevated mutagenesis and decreased DNA repair at a transgene are associated with proliferation but not apoptosis in p53-deficient cells.

Conformational changes in the C terminus of Shaker $K^{+}$ channel bound to the rat Kvβ2-subunit

Detecting elusive surface atoms with atomic force microscopy.

The energetics of structural change in maltose-binding protein.

Convergent evolution of bright coloration and toxicity in frogs.

Using nonequilibrium measurements to determine macromolecule free-energy differences.

The single capillary and the active brain.

β-Adrenergic regulation requires direct anchoring of PKA to cardiac $Ca_{V}1.2$ channels via a leucine zipper interaction with A kinase-anchoring protein 15

Expression of T cell receptor beta locus in central nervous system neurons.

Fast protein folding kinetics.

The Nagata automorphism is wild.

Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI.

Signature quantization.

Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus.

The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA.

Twin concordance and sibling recurrence rates in multiple sclerosis.

Mixotrophs combine resource use to outcompete specialists: implications for aquatic food webs.

The complexity of alternative splicing of hagoromo mRNAs is increased in an explosively speciated lineage in East African cichlids.

Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: electrophysiology-coordinated photochemistry and mass spectrometry.

Two-photon imaging of capillary blood flow in olfactory bulb glomeruli.

Genetic requirements for mycobacterial survival during infection.

Active sites of thioredoxin reductases: why selenoproteins?

The homodimer of prostate-specific membrane antigen is a functional target for cancer therapy.

Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice.

Year: 2003 Volume: 100 Issue: 21

Year: 2003 Volume: 100 Issue: 20

Year: 2003 Volume: 100 Issue: 19

Year: 2003 Volume: 100 Issue: 18

Year: 2003 Volume: 100 Issue: 17

Year: 2003 Volume: 100 Issue: 16

Year: 2003 Volume: 100 Issue: 15

Year: 2003 Volume: 100 Issue: 14

Year: 2003 Volume: 100 Issue: 13

Year: 2003 Volume: 100 Issue: 12

Year: 2003 Volume: 100 Issue: 11

Year: 2003 Volume: 100 Issue: 10

Year: 2003 Volume: 100 Issue: 9

Year: 2003 Volume: 100 Issue: 8

Year: 2003 Volume: 100 Issue: 7

Year: 2003 Volume: 100 Issue: 6

Year: 2003 Volume: 100 Issue: 5

Year: 2003 Volume: 100 Issue: 4

Year: 2003 Volume: 100 Issue: 3

Year: 2003 Volume: 100 Issue: 2

Year: 2003 Volume: 100 Issue: Suppl 2

Year: 2003 Volume: 100 Issue: 1

Year: 2003 Volume: 100 Issue: Suppl 1

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Twin concordance and sibling recurrence rates in multiple sclerosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dyment, D. A. Sadovnick, A. D. Ebers, G. C. Willer, C. J. Risch, N. J.
Spatial Coverage	Canada
Description	Author Affiliation: Willer CJ ( Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.);
Abstract	Size and ascertainment constraints often limit twin studies to concordance comparisons between identical and fraternal twins. Here we report the final results of a longitudinal, population-based study of twins with multiple sclerosis (MS) in Canada. Bias was demonstrably minimized, and an estimated 75% of all Canadian MS twin pairs were ascertained, giving a sample sufficiently large (n = 370) to permit additional informative comparisons. Twinning was not found to affect prevalence, and twins with MS did not differ from nontwins for DR15 allele frequency nor for MS risk to their siblings. Probandwise concordance rates of 25.3% (SE +/- 4.4) for monozygotic (MZ), 5.4% (+/-2.8) for dizygotic (DZ), and 2.9% (+/-0.6) for their nontwin siblings were found. MZ twin concordance was in excess of DZ twin concordance. The excess concordance in MZ was derived primarily from like-sexed female pairs with a probandwise concordance rate of 34 of 100 (34 +/- 5.7%) compared with 3 of 79 (3.8 +/- 2.8%) for female DZ pairs. We did not demonstrate an MZ/DZ difference in males, although the sample size was small. We observed a 2-fold increase in risk to DZ twins over nontwin siblings of twins, but the difference was not significant.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Diseases In Twins Genetics Multiple Sclerosis Canada Epidemiology Databases, Factual Genetic Predisposition To Disease Heterozygote Homozygote Physiopathology Recurrence Registries Statistics & Numerical Data Twins, Dizygotic Twins, Monozygotic Research Support, Non-U.S. Gov't Twin Study Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in