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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nakatani, Yoshihiro Demasi, Joseph Huh, Kyung-won Münger, Karl Howley, Peter M. |
| Description | Author Affiliation: DeMasi J ( Department of Pathology, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.); |
| Abstract | The E7 oncoprotein of bovine papillomavirus type 1 (BPV-1) is required for the full transformation activity of the virus. However, the mechanism by which E7 contributes to cellular transformation is unknown. To address this question, we used the proteomic approach of tandem affinity purification to identify cellular proteins that are in complex with E7, and identified the 600-kDa protein, p600, as a binding partner of E7. The ability of E7 to complex with p600 correlated with its ability to enhance anchorage independence of BPV-1 E6-expressing cells. Furthermore, E7 mutant proteins impaired in their ability to bind p600 were transformation defective. Additionally, knockdown of p600 reduced transformation of cells expressing both BPV-1 E6 and E7, as well as E6 alone, suggesting that the ability of E7 to transformed cells is mediated, at least in part, through its ability to bind p600. These data complement work that shows that HPV16 E7 also interacts with p600, and that this interaction correlates with the ability of HPV16 E7 to transform cells. These studies thus identify p600 as a shared target of the E7 proteins of multiple papillomaviruses. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 32 |
| Volume Number | 102 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2005-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Bovine Papillomavirus 1 Metabolism Calmodulin-Binding Proteins Cell Transformation, Viral Physiology Multiprotein Complexes Oncogene Proteins, Viral Amino Acid Sequence Immunoblotting Immunoprecipitation Molecular Sequence Data Isolation & Purification Genetics RNA Interference Sequence Alignment Comparative Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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