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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kaiser, Dale Jiang, Yi Alber, Mark Sozinova, Olga |
| Description | Author Affiliation: Sozinova O ( Department of Mathematics and Center for the Study of Biocomplexity, University of Notre Dame, Notre Dame, IN 46556-5670, USA.); |
| Abstract | Myxobacteria provide one of the simplest models of cell-cell interaction and organized cell movement leading to cellular differentiation. When starved, tens of thousands of cells change their movement pattern from outward spreading to inward concentration; they form aggregates that become fruiting bodies. Cells inside fruiting bodies differentiate into round, nonmotile, environmentally resistant spores. Traditionally, cell aggregation has been considered to imply chemotaxis; a long-range cell interaction. However, myxobacterial aggregation is the consequence of direct cell-contact interactions, not chemotaxis. We present here a 3D stochastic lattice-gas cellular automata model of cell aggregation based on local cell-cell contact, and no chemotaxis. We demonstrate that a 3D discrete stochastic model can simulate two stages of cell aggregation. First, a 'traffic jam' forms embedded in a field of motile cells. The jam then becomes an aggregation center that accumulates more cells. We show that, at high cell density, cells stream around the traffic jam, generating a 3D hemispherical mound. Later, when the nuclear traffic jam dissolves, the aggregation center becomes a 3D ring of streaming cells. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 32 |
| Volume Number | 102 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2005-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Models, Biological Movement Physiology Myxococcus Xanthus Signal Transduction Spores, Bacterial Comparative Study Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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