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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Delfini, Marie-claire Pourquié, Olivier Chal, Jérome Dubrulle, Julien Malapert, Pascale |
| Description | Author Affiliation: Delfini MC ( Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.); |
| Abstract | The regular spacing of somites during vertebrate embryogenesis involves a dynamic gradient of FGF signaling that controls the timing of maturation of cells in the presomitic mesoderm (PSM). How the FGF signal is transduced by PSM cells is unclear. Here, we first show that the FGF gradient is translated into graded activation of the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway along the PSM in the chicken embryo. Using in ovo electroporation of PSM cells, we demonstrate that constitutive activation of ERK signaling in the PSM blocks segmentation by preventing maturation of PSM cells, thus phenocopying the overexpression of FGF8. Conversely, inhibition of ERK phosphorylation mimics a loss of function of FGF signaling in the PSM. Interestingly, video microscopy analysis of cell movements shows that ERK regulates the motility of PSM cells, suggesting that the decrease of cell movements along the PSM enables mesenchymal PSM cells to undergo proper segmentation. Together, our data demonstrate that ERK is the effector of the gradient of FGF in the PSM that controls the segmentation process. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 32 |
| Volume Number | 102 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2005-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Embryonic Development Physiology Extracellular Signal-Regulated MAP Kinases Metabolism Fibroblast Growth Factors Mesoderm Signal Transduction Somites Animals Blotting, Western Cell Movement Chick Embryo Electroporation Immunohistochemistry In Situ Hybridization Microscopy, Video Microspheres Phosphorylation Comparative Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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