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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cook, Laura C. C. Chen, Yuqing Dunny, Gary M. Manias, Dawn A. Shu, Che-chi Ramkrishna, Doraiswami Chatterjee, Anushree Hu, Wei-shou |
| Description | Author Affiliation: Chatterjee A ( Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.); |
| Abstract | Conjugation is one of the most common ways bacteria acquire antibiotic resistance, contributing to the emergence of multidrug-resistant 'superbugs.' Bacteria of the genus Enterococcus faecalis are highly antibiotic-resistant nosocomial pathogens that use the mechanism of conjugation to spread antibiotic resistance between resistance-bearing donor cells and resistance-deficient recipient cells. Here, we report a unique quorum sensing-based communication system that uses two antagonistic signaling molecules to regulate conjugative transfer of tetracycline-resistance plasmid pCF10 in E. faecalis. A 'mate-sensing' peptide sex pheromone produced by recipient cells is detected by donor cells to induce conjugative genetic transfer. Using mathematical modeling and experimentation, we show that a second antagonistic 'self-sensing' signaling peptide, previously known to suppress self-induction of donor cells, also serves as a classic quorum-sensing signal for donors that functions to reduce antibiotic-resistance transfer at high donor density. This unique form of quorum sensing may provide a means of limiting the spread of the plasmid and present opportunities to control antibiotic-resistance transfer through manipulation of intercellular signaling, with implications in the clinical setting. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 17 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Conjugation, Genetic Physiology Drug Resistance, Bacterial Genetics Enterococcus Faecalis Models, Biological Protein Sorting Signals Quorum Sensing Plasmids Real-Time Polymerase Chain Reaction Sex Attractants Metabolism Tetracycline Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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