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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kikuta, Junichi Sakai, Sadaoki Okiji, Fumie Shirazaki, Mai Kawamura, Shunsuke Ishii, Masaru Saito, Hitoshi |
| Description | Author Affiliation: Kikuta J ( Laboratory of Cellular Dynamics, Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.); |
| Abstract | The migration and positioning of osteoclast precursor monocytes are controlled by the blood-enriched lipid mediator sphingosine-1-phosphate (S1P) and have recently been shown to be critical points of control in osteoclastogenesis and bone homeostasis. Here, we show that calcitriol, which is the hormonally active form of vitamin D, and its therapeutically used analog, eldecalcitol, inhibit bone resorption by modulating this mechanism. Vitamin D analogs have been used clinically for treating osteoporosis, although the mode of its pharmacologic action remains to be fully elucidated. In this study, we found that active vitamin D reduced the expression of S1PR2, a chemorepulsive receptor for blood S1P, on circulating osteoclast precursor monocytes both in vitro and in vivo. Calcitriol- or eldecalcitol-treated monocytoid RAW264.7 cells, which display osteoclast precursor-like properties, migrated readily to S1P. Concordantly, the mobility of circulating $CX_{3}CR1^{+}$ osteoclast precursor monocytes was significantly increased on systemic administration of active vitamin D. These results show a mechanism for active vitamin D in controlling the migratory behavior of circulating osteoclast precursors, and this action should be conducive to limiting osteoclastic bone resorption in vivo. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 17 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Bone Density Conservation Agents Metabolism Calcitriol Cell Movement Physiology Lysophospholipids Monocytes Receptors, Lysosphingolipid Sphingosine Analogs & Derivatives Vitamin D Absorptiometry, Photon Animals Bone Density Cell Line DNA Primers Genetics Mice Mice, Inbred C57BL Osteoclasts Cytology Real-Time Polymerase Chain Reaction Statistics, Nonparametric Pharmacology Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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