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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Neher, Erwin Ho, Won-kyung Lee, Jae Sung Lee, Suk-ho |
| Description | Author Affiliation: Lee JS ( Cell Physiology Laboratory, Department of Physiology and Bio-Membrane Plasticity Research Center, Seoul National University College of Medicine and Neuroscience Research Institute, Seoul National University Medical Research Center, Seoul 110-799, Republic of Korea.); |
| Abstract | Recruitment of release-competent vesicles during sustained synaptic activity is one of the major factors governing short-term plasticity. During bursts of synaptic activity, vesicles are recruited to a fast-releasing pool from a reluctant vesicle pool through an actin-dependent mechanism. We now show that newly recruited vesicles in the fast-releasing pool do not respond at full speed to a strong $Ca^{2+}$ stimulus, but require approximately 4 s to mature to a “superprimed” state. Superpriming was found to be altered by agents that modulate the function of unc13 homolog proteins (Munc13s), but not by calmodulin inhibitors or actin-disrupting agents. These findings indicate that recruitment and superpriming of vesicles are regulated by separate mechanisms, which require integrity of the cytoskeleton and activation of Munc13s, respectively. We propose that refilling of the fast-releasing vesicle pool proceeds in two steps, rapid actin-dependent “positional priming,” which brings vesicles closer to $Ca^{2+}$ sources, followed by slower superpriming, which enhances the $Ca^{2+}$ sensitivity of primed vesicles. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 37 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Synaptic Vesicles Physiology Actins Metabolism Animals Brain Stem Drug Effects Calcium Signaling Calmodulin Diglycerides Pharmacology Estrenes Excitatory Postsynaptic Potentials Kinetics Models, Neurological Nerve Tissue Proteins Phosphodiesterase Inhibitors Pyrrolidinones Rats, Sprague-Dawley Type C Phospholipases Antagonists & Inhibitors Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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