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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hitchcock, Charles He, Qianchuan Nana-sinkam, Patrick Cui, Ri Yu, Jianhua Wei, Huijun Peng, Yong Luo, Zhenghua Jeon, Young-jun Liu, Lunxu Lee, Tae Jin Nuovo, Gerard J. Dai, Yuntao Croce, Carlo M. Kim, Taewan Sun, Hui-lung Volinia, Stefano Yang, Xiaojuan Kassis, Edmund S. |
| Description | Author Affiliation: Peng Y ( Department of Molecular Virology, Immunology, and Medical Genetics and Division of Hematology, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.); |
| Abstract | MicroRNAs (miRNAs) are small 19- to 24-nt noncoding RNAs that have the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In cancer, miRNAs may function as oncogenes or tumor suppressors. Here, we conducted global profiling for miRNAs in a cohort of stage 1 nonsmall cell lung cancers (n = 81) and determined that miR-486 was the most down-regulated miRNA in tumors compared with adjacent uninvolved lung tissues, suggesting that miR-486 loss may be important in lung cancer development. We report that miR-486 directly targets components of insulin growth factor (IGF) signaling including insulin-like growth factor 1 (IGF1), IGF1 receptor (IGF1R), and phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1, or p85a) and functions as a potent tumor suppressor of lung cancer both in vitro and in vivo. Our findings support the role for miR-486 loss in lung cancer and suggest a potential biological link to p53. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 37 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Carcinoma, Non-Small-Cell Lung Genetics Metabolism Class Ia Phosphatidylinositol 3-Kinase Insulin-Like Growth Factor I Lung Neoplasms MicroRNAs Receptor, IGF Type 1 3' Untranslated Regions Animals Apoptosis Pathology Cell Cycle Checkpoints Cell Line, Tumor Cell Movement Cell Proliferation Antagonists & Inhibitors Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Genes, P53 Mice Mice, Nude RNA, Small Interfering Signal Transduction Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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