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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gapin, Laurent Pennock, Nathan D. Kedl, Ross M. |
| Description | Author Affiliation: Pennock ND ( Department of Immunology and Microbiology, University of Colorado Denver, Aurora, CO 80045.); Gapin L ( Department of Immunology and Microbiology, University of Colorado Denver, Aurora, CO 80045.); Kedl RM ( Department of Immunology and Microbiology, University of Colorado Denver, Aurora, CO 80045 ross.kedl@ucdenver.edu.); |
| Abstract | An elusive goal of cellular immune vaccines is the generation of large numbers of antigen-specific T cells in response to subunit immunization. A broad spectrum of cytokines and cell-surface costimulatory molecules are known to shape the programming, magnitude, and repertoire of T cells responding to vaccination. We show here that the majority of innate immune receptor agonist-based vaccine adjuvants unexpectedly depend on IL-27 for eliciting CD4(+) and CD8(+) T-cell responses. This is in sharp contrast to infectious challenge, which generates T-cell responses that are IL-27-independent. Mixed bone marrow chimera experiments demonstrate that IL-27 dependency is T cell-intrinsic, requiring T-cell expression of IL-27R . Further, we show that IL-27 dependency not only dictates the magnitude of vaccine-elicited T-cell responses but also is critical for the programming and persistence of high-affinity T cells to subunit immunization. Collectively, our data highlight the unexpected central importance of IL-27 in the generation of robust, high-affinity cellular immune responses to subunit immunization. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 46 |
| Volume Number | 111 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2014-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adaptive Immunity Immunology Bacterial Vaccines Interleukins Physiology T-Lymphocyte Subsets Vaccination Adjuvants, Immunologic Adoptive Transfer Animals Antigens, CD40 Immunologic Memory Listeriosis Prevention & Control Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Ovalbumin Poly I-C Radiation Chimera Receptors, Cytokine Deficiency STAT Transcription Factors Smallpox Vaccine T-Cell Antigen Receptor Specificity Toll-Like Receptors Transcription, Genetic Vaccines, Subunit Vaccinia Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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