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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Steinberg, Ethan Song, Ying Yozzo, Alexander Kohn, Michael H. Liu, Kevin J. Nakhleh, Luay |
| Description | Author Affiliation: Liu KJ ( Department of Computer Science and nakhleh@rice.edu kjl@msu.edu hmkohn@rice.edu.); Steinberg E ( Department of Computer Science and.); Yozzo A ( Department of Computer Science and.); Song Y ( BioSciences, Rice University, Houston, TX 77005.); Kohn MH ( BioSciences, Rice University, Houston, TX 77005 nakhleh@rice.edu kjl@msu.edu hmkohn@rice.edu.); Nakhleh L ( Department of Computer Science and BioSciences, Rice University, Houston, TX 77005 nakhleh@rice.edu kjl@msu.edu hmkohn@rice.edu.); |
| Abstract | We report on a genome-wide scan for introgression between the house mouse (Mus musculus domesticus) and the Algerian mouse (Mus spretus), using samples from the ranges of sympatry and allopatry in Africa and Europe. Our analysis reveals wide variability in introgression signatures along the genomes, as well as across the samples. We find that fewer than half of the autosomes in each genome harbor all detectable introgression, whereas the X chromosome has none. Further, European mice carry more M. spretus alleles than the sympatric African ones. Using the length distribution and sharing patterns of introgressed genomic tracts across the samples, we infer, first, that at least three distinct hybridization events involving M. spretus have occurred, one of which is ancient, and the other two are recent (one presumably due to warfarin rodenticide selection). Second, several of the inferred introgressed tracts contain genes that are likely to confer adaptive advantage. Third, introgressed tracts might contain driver genes that determine the evolutionary fate of those tracts. Further, functional analysis revealed introgressed genes that are essential to fitness, including the Vkorc1 gene, which is implicated in rodenticide resistance, and olfactory receptor genes. Our findings highlight the extent and role of introgression in nature and call for careful analysis and interpretation of house mouse data in evolutionary and genetic studies. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 1 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Crosses, Genetic Genetic Variation Genome Genetics Animals Geography Haploidy Hybridization, Genetic Mice Species Specificity Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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