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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rosenberg, Susan M. Vyawahare, Saurabh Zhang, Qiucen Bos, Julia Rogers, Elizabeth Austin, Robert H. |
| Description | Author Affiliation: Bos J ( Department of Physics, Princeton University, Princeton, NJ 08544-0708); Zhang Q ( Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801-3080); Vyawahare S ( Department of Physics, Princeton University, Princeton, NJ 08544-0708); Rogers E ( Departments of Molecular and Human Genetics, Biochemistry and Molecular Biology, and Molecular Virology and Microbiology, and the Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030.); Rosenberg SM ( Departments of Molecular and Human Genetics, Biochemistry and Molecular Biology, and Molecular Virology and Microbiology, and the Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030.); Austin RH ( Department of Physics, Princeton University, Princeton, NJ 08544-0708); |
| Abstract | Bacteria can rapidly evolve resistance to antibiotics via the SOS response, a state of high-activity DNA repair and mutagenesis. We explore here the first steps of this evolution in the bacterium Escherichia coli. Induction of the SOS response by the genotoxic antibiotic ciprofloxacin changes the E. coli rod shape into multichromosome-containing filaments. We show that at subminimal inhibitory concentrations of ciprofloxacin the bacterial filament divides asymmetrically repeatedly at the tip. Chromosome-containing buds are made that, if resistant, propagate nonfilamenting progeny with enhanced resistance to ciprofloxacin as the parent filament dies. We propose that the multinucleated filament creates an environmental niche where evolution can proceed via generation of improved mutant chromosomes due to the mutagenic SOS response and possible recombination of the new alleles between chromosomes. Our data provide a better understanding of the processes underlying the origin of resistance at the single-cell level and suggest an analogous role to the eukaryotic aneuploidy condition in cancer. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 1 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Drug Resistance, Microbial Escherichia Coli Cytology Physiology Asymmetric Cell Division Drug Effects Chromosomes, Bacterial Metabolism Ciprofloxacin Pharmacology Isolation & Purification Models, Biological Sequence Analysis, DNA Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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