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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Charest, Joseph L. Kamm, Roger D. Moretti, Matteo Jeon, Jessie S. Gilardi, Mara Dubini, Gabriele Bersini, Simone |
| Description | Author Affiliation: Jeon JS ( Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139); Bersini S ( Department of Electronics, Information and Bioengineering, Politecnico di Milano, 20133 Milan, Italy); Gilardi M ( Cell and Tissue Engineering Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Ortopedico Galeazzi, 20161 Milan, Italy); Dubini G ( Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano, 20133 Milan, Italy); Charest JL ( Charles Stark Draper Laboratory, Cambridge, MA 02139); Moretti M ( Cell and Tissue Engineering Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Ortopedico Galeazzi, 20161 Milan, Italy); Kamm RD ( Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139); |
| Abstract | A key aspect of cancer metastases is the tendency for specific cancer cells to home to defined subsets of secondary organs. Despite these known tendencies, the underlying mechanisms remain poorly understood. Here we develop a microfluidic 3D in vitro model to analyze organ-specific human breast cancer cell extravasation into bone- and muscle-mimicking microenvironments through a microvascular network concentrically wrapped with mural cells. Extravasation rates and microvasculature permeabilities were significantly different in the bone-mimicking microenvironment compared with unconditioned or myoblast containing matrices. Blocking breast cancer cell A3 adenosine receptors resulted in higher extravasation rates of cancer cells into the myoblast-containing matrices compared with untreated cells, suggesting a role for adenosine in reducing extravasation. These results demonstrate the efficacy of our model as a drug screening platform and a promising tool to investigate specific molecular pathways involved in cancer biology, with potential applications to personalized medicine. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 1 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Breast Neoplasms Blood Supply Pathology Extravasation Of Diagnostic And Therapeutic Materials Diagnosis Microfluidics Microvessels Adenosine Metabolism Animals Capillary Permeability Cell Line, Tumor Cellular Microenvironment Human Umbilical Vein Endothelial Cells Mice Shear Strength Stress, Mechanical Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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