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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chen, Arlene Li, Huai Haley, Bradd J. Hasan, Nur A. Alam, Munirul Su, Qi Huq, Anwar Colwell, Rita R. Fraser-liggett, Claire M. Ravel, Jacques Furth, Keziah Tallon, Luke J. Cebula, Thomas A. Choi, Seon Young Hine, Erin Cravioto, Alejandro Prosper, Joseph B. Hoq, M. M. Eppinger, Mark Clark, Philip W. Taviani, Elisa |
| Spatial Coverage | Haiti |
| Description | Author Affiliation: Hasan NA ( Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA.); |
| Abstract | The millions of deaths from cholera during the past 200 y, coupled with the morbidity and mortality of cholera in Haiti since October 2010, are grim reminders that Vibrio cholerae, the etiologic agent of cholera, remains a scourge. We report the isolation of both V. cholerae O1 and non-O1/O139 early in the Haiti cholera epidemic from samples collected from victims in 18 towns across eight Arrondissements of Haiti. The results showed two distinct populations of V. cholerae coexisted in Haiti early in the epidemic. As non-O1/O139 V. cholerae was the sole pathogen isolated from 21% of the clinical specimens, its role in this epidemic, either alone or in concert with V. cholerae O1, cannot be dismissed. A genomic approach was used to examine similarities and differences among the Haitian V. cholerae O1 and V. cholerae non-O1/O139 strains. A total of 47 V. cholerae O1 and 29 V. cholerae non-O1/O139 isolates from patients and the environment were sequenced. Comparative genome analyses of the 76 genomes and eight reference strains of V. cholerae isolated in concurrent epidemics outside Haiti and 27 V. cholerae genomes available in the public database demonstrated substantial diversity of V. cholerae and ongoing flux within its genome. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 29 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cholera Epidemiology Microbiology Disease Outbreaks Genetic Variation Genome, Bacterial Genetics Vibrio Cholerae Bacterial Proteins Haiti Molecular Sequence Annotation Molecular Sequence Data Polymorphism, Single Nucleotide Principal Component Analysis Sequence Analysis, DNA Species Specificity Tandem Repeat Sequences Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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