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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chen, Jonathan C. Botstein, David Rabinowitz, Joshua D. Schieler, Ariel Gibney, Patrick A. |
| Description | Author Affiliation: Gibney PA ( Lewis-Sigler Institute for Integrative Genomics and Departments of Molecular Biology and.); Schieler A ( Lewis-Sigler Institute for Integrative Genomics and.); Chen JC ( Lewis-Sigler Institute for Integrative Genomics and Chemistry, Princeton University, Princeton, NJ 08544.); Rabinowitz JD ( Lewis-Sigler Institute for Integrative Genomics and Chemistry, Princeton University, Princeton, NJ 08544.); Botstein D ( Lewis-Sigler Institute for Integrative Genomics and Departments of Molecular Biology and botstein@princeton.edu.); |
| Abstract | Trehalose is a highly stable, nonreducing disaccharide of glucose. A large body of research exists implicating trehalose in a variety of cellular phenomena, notably response to stresses of various kinds. However, in very few cases has the role of trehalose been examined directly in vivo. Here, we describe the development and characterization of a system in Saccharomyces cerevisiae that allows us to manipulate intracellular trehalose concentrations independently of the biosynthetic enzymes and independently of any applied stress. We found that many physiological roles heretofore ascribed to intracellular trehalose, including heat resistance, are not due to the presence of trehalose per se. We also found that many of the metabolic and growth defects associated with mutations in the trehalose biosynthesis pathway are not abolished by providing abundant intracellular trehalose. Instead, we made the observation that intracellular accumulation of trehalose or maltose (another disaccharide of glucose) is growth-inhibitory in a carbon source-specific manner. We conclude that the physiological role of the trehalose pathway is fundamentally metabolic: i.e., more complex than simply the consequence of increased concentrations of the sugar and its attendant physical properties (with the exception of the companion paper where Tapia et al. [Tapia H, et al. (2015) Proc Natl Acad Sci USA, 10.1073/pnas.1506415112] demonstrate a direct role for trehalose in protecting cells against desiccation). |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 19 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Monosaccharide Transport Proteins Metabolism Saccharomyces Cerevisiae Proteins Saccharomyces Cerevisiae Symporters Trehalose Biological Transport Gene Expression Profiling Gene Expression Regulation, Fungal Glucose Hot Temperature Maltose Metabolomics Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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