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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Levy, Sagi Kafri, Moshe Carmi, Miri Barkai, Naama |
| Description | Author Affiliation: Levy S ( Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.) |
| Abstract | Cells use transporters of different affinities to regulate nutrient influx. When nutrients are depleted, low-affinity transporters are replaced by high-affinity ones. High-affinity transporters are helpful when concentrations of nutrients are low, but the advantage of reducing their abundance when nutrients are abundant is less clear. When we eliminated such reduced production of the Saccharomyces cerevisiae high-affinity transporters for phosphate and zinc, the elapsed time from the initiation of the starvation program until the lack of nutrients limited growth was shortened, and recovery from starvation was delayed. The latter phenotype was rescued by constitutive activation of the starvation program. Dual-transporter systems appear to prolong preparation for starvation and to facilitate subsequent recovery, which may optimize sensing of nutrient depletion by integrating internal and external information about nutrient availability. |
| ISSN | 00368075 |
| e-ISSN | 10959203 |
| Journal | Science |
| Issue Number | 6061 |
| Volume Number | 334 |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2011-12-09 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cation Transport Proteins Metabolism Phosphate Transport Proteins Proton-Phosphate Symporters Saccharomyces Cerevisiae Proteins Saccharomyces Cerevisiae Genetics Culture Media Gene Expression Profiling Gene Expression Regulation, Fungal Homeostasis Phenotype Phosphates Growth & Development Zinc Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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