| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Yutuc, Vernon Johnson, Trevor Ferrier, Clayton Sackett, Gene P. Gunn, Howard Gadad, Bharathi S. German, Dwight C. Young, Keith Yazdani, Umar Marti, C. Nathan Curtis, Britni Hammond, Jacob Li, Wenhao Grady, Stephen English, Chris Hewitson, Laura |
| Description |
Author Affiliation: Gadad BS ( Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390); Li W ( Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390); Yazdani U ( Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390); Grady S ( Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390); Johnson T ( Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390); Hammond J ( Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390); Gunn H ( Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390); Curtis B ( Infant Primate Research Laboratory, Washington National Primate Research Center, Seattle, WA 98195); English C ( Infant Primate Research Laboratory, Washington National Primate Research Center, Seattle, WA 98195); Yutuc V ( Infant Primate Research Laboratory, Washington National Primate Research Center, Seattle, WA 98195); Ferrier C ( Infant Primate Research Laboratory, Washington National Primate Research Center, Seattle, WA 98195); Sackett GP ( Infant Primate Research Laboratory, Washington National Primate Research Center, Seattle, WA 98195); Marti CN ( Independent Consultant, Austin, TX 78711); Young K ( Department of Psychiatry and Behavioral Science, Texas A&M Health Science Center & Central Texas Veterans Health Care System, Temple, TX 76504); Hewitson L ( Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390); German DC ( Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390); |
| Abstract |
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Some anecdotal reports suggest that ASD is related to exposure to ethyl mercury, in the form of the vaccine preservative, thimerosal, and/or receiving the measles, mumps, rubella (MMR) vaccine. Using infant rhesus macaques receiving thimerosal-containing vaccines (TCVs) following the recommended pediatric vaccine schedules from the 1990s and 2008, we examined behavior, and neuropathology in three brain regions found to exhibit neuropathology in postmortem ASD brains. No neuronal cellular or protein changes in the cerebellum, hippocampus, or amygdala were observed in animals following the 1990s or 2008 vaccine schedules. Analysis of social behavior in juvenile animals indicated that there were no significant differences in negative behaviors between animals in the control and experimental groups. These data indicate that administration of TCVs and/or the MMR vaccine to rhesus macaques does not result in neuropathological abnormalities, or aberrant behaviors, like those observed in ASD. |
| ISSN |
00278424 |
| e-ISSN |
10916490 |
| Journal |
Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number |
40 |
| Volume Number |
112 |
| Language |
English |
| Publisher |
National Academy of Sciences |
| Publisher Date |
2015-10-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Autistic Disorder Diagnosis Brain Diseases Thimerosal Administration & Dosage Vaccines Amygdala Drug Effects Metabolism Animals Animals, Newborn Chemically Induced Blotting, Western Calbindins Calcium-Binding Proteins Cerebellum Glial Fibrillary Acidic Protein Glutamate Decarboxylase Hippocampus Immunohistochemistry Macaca Mulatta Microfilament Proteins Neurons Neuropathology Preservatives, Pharmaceutical Adverse Effects Time Factors Vaccination Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Multidisciplinary |
