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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sejnowski, Terrence J. Cortes, Jesus M. Ali, Afia B. Rodrigues, Serafim Krupa, Martin Desroches, Mathieu |
| Description | Author Affiliation: Rodrigues S ( School of Computing and Mathematics, Plymouth University, Plymouth PL4 8AA, United Kingdom); Desroches M ( Inria Sophia Antipolis Mediterranee Research Centre, MathNeuro Team, 06902 Sophia Antipolis cedex, France); Krupa M ( Inria Sophia Antipolis Mediterranee Research Centre, MathNeuro Team, 06902 Sophia Antipolis cedex, France); Cortes JM ( Biocruces Health Research Institute, Cruces University Hospital, 48903 Barakaldo, Bizkaia, Spain); Sejnowski TJ ( The Computational Neurobiology Laboratory, Salk Institute, La Jolla, CA 92037); Ali AB ( UCL School of Pharmacy, Department of Pharmacology, University College London, London WC1N 1AX, United Kingdom.); |
| Abstract | Communication between neurons at chemical synapses is regulated by hundreds of different proteins that control the release of neurotransmitter that is packaged in vesicles, transported to an active zone, and released when an input spike occurs. Neurotransmitter can also be released asynchronously, that is, after a delay following the spike, or spontaneously in the absence of a stimulus. The mechanisms underlying asynchronous and spontaneous neurotransmitter release remain elusive. Here, we describe a model of the exocytotic cycle of vesicles at excitatory and inhibitory synapses that accounts for all modes of vesicle release as well as short-term synaptic plasticity (STSP). For asynchronous release, the model predicts a delayed inertial protein unbinding associated with the SNARE complex assembly immediately after vesicle priming. Experiments are proposed to test the model's molecular predictions for differential exocytosis. The simplicity of the model will also facilitate large-scale simulations of neural circuits. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 8 |
| Volume Number | 113 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2016-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Exocytosis Physiology Neural Conduction Neuronal Plasticity Neurotransmitter Agents Secretion Synaptic Vesicles Metabolism Animals Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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