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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hu, Zhitao Kaplan, Joshua M. Hom, Sabrina Choi, Seungwon Kudze, Tambudzai Aramuni, Gayane Zhang, Weiqi Tong, Xia-jing |
| Description | Author Affiliation: Hu Z ( Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.) |
| Abstract | The synaptic adhesion molecules neurexin and neuroligin alter the development and function of synapses and are linked to autism in humans. Here, we found that Caenorhabditis elegans neurexin (NRX-1) and neuroligin (NLG-1) mediated a retrograde synaptic signal that inhibited neurotransmitter release at neuromuscular junctions. Retrograde signaling was induced in mutants lacking a muscle microRNA (miR-1) and was blocked in mutants lacking NLG-1 or NRX-1. Release was rapid and abbreviated when the retrograde signal was on, whereas release was slow and prolonged when retrograde signaling was blocked. The retrograde signal adjusted release kinetics by inhibiting exocytosis of synaptic vesicles (SVs) that are distal to the site of calcium entry. Inhibition of release was mediated by increased presynaptic levels of tomosyn, an inhibitor of SV fusion. |
| ISSN | 00368075 |
| e-ISSN | 10959203 |
| Journal | Science |
| Issue Number | 6097 |
| Volume Number | 337 |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2012-08-24 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Caenorhabditis Elegans Proteins Metabolism Caenorhabditis Elegans Physiology Cell Adhesion Molecules, Neuronal Neuromuscular Junction Synaptic Transmission Acetylcholine Animals Genetics Cholinergic Neurons Excitatory Postsynaptic Potentials Exocytosis Kinetics Mice MicroRNAs Motor Neurons Mutation Neural Inhibition Neurotransmitter Agents Synaptic Vesicles Transcription Factors Transfection Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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