NDLI: Palm tocotrienol-rich fraction reduced plasma homocysteine and heart oxidative stress in rats fed with a high-methionine diet.

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Palm tocotrienol-rich fraction reduced plasma homocysteine and heart oxidative stress in rats fed with a high-methionine diet.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Norsidah, Ku-Zaifah Asmadi, Ahmad Yusof Azizi, Ayob Faizah, Othman Kamisah, Yusof
Description	Country affiliation: Malaysia Author Affiliation: Norsidah KZ ( Department of Basic Medical Sciences, Kuliyyah of Medicine, International Islamic University of Malaysia, Pahang, Malaysia.)
Abstract	Oxidative stress contributes to cardiovascular diseases. We aimed to study the effects of palm tocotrienol-rich fraction (TRF) on plasma homocysteine and cardiac oxidative stress in rats fed with a high-methionine diet. Forty-two male Wistar rats were divided into six groups. The first group was the control. Groups 2-6 were fed 1% methionine diet for 10 weeks. From week 6 onward, folate (8 mg/kg diet) or palm TRF (30, 60 and 150 mg/kg diet) was added into the diet of groups 3, 4, 5 and 6. The rats were then killed. Palm TRF at 150 mg/kg and folate supplementation prevented the increase in plasma total homocysteine (4.14 ± 0.33 and 4.30 ± 0.26 vs 5.49 ± 0.25 mmol/L, p < 0.05) induced by a high-methionine diet. The increased heart thiobarbituric acid reactive substance in rats fed with high-methionine diet was also prevented by the supplementations of palm TRF (60 and 150 mg/kg) and folate. The high-methionine group had a lower glutathione peroxidase activity (49 ± 3 vs 69 ± 4 pmol/mg protein/min) than the control group. This reduction was reversed by palm TRF at 60 and 150 mg/kg diet (p < 0.05), but not by folate. Catalase and superoxide dismutase activities were unaffected by both methionine and vitamin supplementations. In conclusion, palm TRF was comparable to folate in reducing high-methionine diet-induced hyperhomocysteinemia and oxidative stress in the rats' hearts. However, palm TRF was more effective than folate in preserving the heart glutathione peroxidase enzyme activity.
File Format	HTM / HTML
ISSN	11387548
Issue Number	3
Volume Number	69
e-ISSN	18778755
Journal	Journal of Physiology and Biochemistry
Language	English
Publisher	Springer
Publisher Date	2013-09-01
Publisher Place	Spain
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Physiology Discipline Biochemistry Cycas Chemistry Dietary Supplements Hyperhomocysteinemia Prevention & Control Methionine Adverse Effects Plant Extracts Tocotrienols Administration & Dosage Administration, Oral Animals Catalase Metabolism Diet Folic Acid Glutathione Peroxidase Heart Drug Effects Homocysteine Blood Chemically Induced Male Rats Rats, Wistar Superoxide Dismutase Thiobarbituric Acid Reactive Substances Isolation & Purification Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Medicine Biochemistry

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Palm tocotrienol-rich fraction reduced plasma homocysteine and heart oxidative stress in rats fed with a high-methionine diet.