NDLI: Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model.

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Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Barp, Jaqueline Sartório, Carmem Luiza Campos, Cristina Llesuy, Susana Francisca Araujo, Alex Sander Belló-Klein, Adriane
Description	Country affiliation: Brazil Author Affiliation: Barp J ( Cardiovascular Physiology Laboratory, Federal University of Rio Grande do Sul, CEP, Porto Alegre, Brazil.)
Abstract	The aim of this study was to evaluate the potential influence of endogenous ovarian hormones on cardiac oxidative stress in renovascular hypertension. Female Wistar rats (N = 10 per group) were divided among 4 groups: (i) normotensive control; (ii) hypertensive control; (iii) normotensive ovariectomized; and (iv) hypertensive ovariectomized rats. To induce hypertension, 2-kidney 1-clip (2K1C) Goldblatt's method was followed. Blood pressure (BP) was enhanced (25%) in 2K1C and it was not further altered in hypertensive ovariectomized animals. Lipid peroxidation (measured by thiobarbituric acid reactive substances; TBARS) increased in heart homogenates after ovariectomy (253%) and was additionally augmented when associated with hypertension (by 28%). Superoxide dismutase and catalase activities were similar in both hypertensive groups. Hypertension enhanced glutathione peroxidase activity (75%), but the association with ovariectomy prevented this change. Total radical trapping antioxidant potential (TRAP) decreased in hypertensive rats (34%) and was recovered when associated with ovariectomy. However, this adaptation seems not to be sufficient to avoid the increased oxidative damage in ovariectomized hypertensive animals. These results suggest a protective role for physiological ovarian hormones in the cardiac oxidative stress induced by 2K1C hypertension.
File Format	HTM / HTML
ISSN	00084212
e-ISSN	12057541
Journal	Canadian Journal of Physiology and Pharmacology
Issue Number	9
Volume Number	90
Language	English
Publisher	Canadian Science Publishing
Publisher Date	2012-09-01
Publisher Place	Canada
Access Restriction	Open
Subject Keyword	Discipline Physiology Discipline Pharmacology Hypertension, Renovascular Metabolism Myocardium Ovariectomy Oxidative Stress Animals Blood Pressure Catalase Disease Models, Animal Estrogens Glutathione Peroxidase Lipid Peroxidation Enzymology Rats, Wistar Superoxide Dismutase Thiobarbituric Acid Reactive Substances
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Pharmacology

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