NDLI: Shifting to a control diet after a high-fat, high-sucrose diet intake induces epigenetic changes in retroperitoneal adipocytes of Wistar rats.

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Shifting to a control diet after a high-fat, high-sucrose diet intake induces epigenetic changes in retroperitoneal adipocytes of Wistar rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Uriarte, G. Paternain, L. Milagro, F. I. Martínez, J. A. Campion, J.
Description	Country affiliation: Spain Author Affiliation: Uriarte G ( Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain.)
Abstract	The aim of the study was to analyze the phenotypic and epigenetic changes induced by the shift to a chow diet after an obesogenic environment. Animals were randomized to fed chow (control group) or high-fat-sucrose diet (HFS). After 10 weeks, half of the rats fed with HFS diet were reassigned to a chow diet (rest group) while the other half continued with the obesogenic diet (HFS group) until week 20. Changes in fat content, biochemical profile, and DNA methylation levels of several gene promoters from retroperitoneal adipocytes were analyzed. HFS diet intake for 10 weeks induced obese phenotype in the animals, increasing body weight and fat content. These effects were maintained until the end of the trial in HFS group, where an increase in liver fat content, a modification of lipid profile, and retroperitoneal adipose tissue hypertrophy were also observed. Changing the dietary pattern reversed these parameters. Epigenetic analysis showed that HFS diet intake for 20 weeks hypermethylated several CpG sites (6.7 and 29.30) and hypomethylated CpG site 15 from leptin gene promoter. Moreover, the obesogenic diet also hypomethylated CpG site 1 from Fasn (fatty acid synthase) gene promoter, without changes on Ppargc1a (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), Srebf1 (sterol regulatory element-binding transcription factor 1), and aquaporin 7. Shifting to a chow diet reverted HFS-induced DNA methylation levels of some CpG sites of leptin promoter. Changing the dietary pattern hypomethylated a CpG site of Srebf1 and hypermethylated other CpGs on Ppargc1a and Fasn promoter. This study shed light on the reversibility of phenotypical and epigenetic changes induced by a HFS diet intake.
File Format	HTM / HTML
ISSN	11387548
Issue Number	3
Volume Number	69
e-ISSN	18778755
Journal	Journal of Physiology and Biochemistry
Language	English
Publisher	Springer
Publisher Date	2013-09-01
Publisher Place	Spain
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Physiology Discipline Biochemistry Adipocytes Metabolism Diet, High-fat Adverse Effects Epigenesis, Genetic Intra-abdominal Fat Obesity Genetics Pathology Animals Aquaporins Cpg Islands Dna Methylation Fatty Acid Synthase, Type I Leptin Liver Male Etiology Promoter Regions, Genetic Rats Rats, Wistar Sterol Regulatory Element Binding Protein 1 Sucrose Transcription Factors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Medicine Biochemistry

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