NDLI: Influence of diabetes mellitus on long-term outcomes of patients with unprotected left main coronary artery disease treated with either drug-eluting stents or coronary artery bypass grafting.

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Year: 2015 Volume: 56 Issue: Supplementary

Influence of diabetes mellitus on long-term outcomes of patients with unprotected left main coronary artery disease treated with either drug-eluting stents or coronary artery bypass grafting.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yu, Xianpeng He, Jiqiang Luo, Yawei Yuan, Fei Song, Xiantao Gao, Yuechun Li, Quan Huang, Fangjiong Gu, Chengxiong Lv, Shuzheng Chen, Fang
Spatial Coverage	China
Description	Author Affiliation: Yu X ( Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University.)
Abstract	Whether the effect of diabetes on patients with unprotected left main coronary artery (ULMCA) disease differs according to different strategies of revascularization was unknown. This study was conducted to evaluate the impact of diabetes on patients with ULMCA disease treated with either percutaneous coronary intervention (PCI) or coronary-artery bypass grafting (CABG).A total of 922 patients with ULMCA disease who received drug-eluting stent (DES) (n = 465) implantation or underwent CABG (n = 457) were retrospectively analyzed. We compared the effects of these 2 treatments on clinical outcomes (death, myocardial infarction, stroke, repeat revascularization, and the composite of death, myocardial infarction, or stroke), according to diabetic status.During the median follow-up of 7.1 years (interquartile range, 5.3 to 8.2 years), no difference was found between PCI and CABG in the adjusted occurrence of death (P = 0.112) and the composite endpoints of death, myocardial infarction, and stroke (P = 0.235). Significantly higher incidence of repeat revascularization (P < 0.001) was observed in the DES group, whereas the CABG group had a significantly higher rate of stroke (P = 0.001). These trends were consistent in both diabetic and nondiabetic patients. We did not observe significant interactions between treatment outcomes and the presence or absence of diabetes after adjustment for covariates (P(interaction) = 0.580 for the composite of death, MI and stroke, P(interaction) = 0.685 for death, P(interaction) = 0.416 for MI, P(interaction) = 0.470 for stroke, and P(interaction) = 0.502 for repeat revascularization).Presence of diabetes was not important for decision-making between CABG and PCI in patients with ULMCA disease.
File Format	HTM / HTML
ISSN	13492365
e-ISSN	13493299
Journal	International Heart Journal
Issue Number	1
Volume Number	56
Language	English
Publisher	International Heart Journal Association
Publisher Date	2015-01-01
Publisher Place	Japan
Access Restriction	Open
Subject Keyword	Discipline Cardiology Coronary Artery Bypass Coronary Artery Disease Coronary Restenosis Diabetes Mellitus Epidemiology Percutaneous Coronary Intervention Postoperative Complications Stroke Comorbidity Adverse Effects Diagnosis Surgery Etiology Drug-eluting Stents Kaplan-meier Estimate Risk Assessment Risk Factors
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

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