NDLI: Angiographic patterns of restenosis with 2nd generation drug-eluting stent: comparative analysis from a 10-year single-center experience .

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Year: 2015 Volume: 56 Issue: Supplementary

Angiographic patterns of restenosis with 2nd generation drug-eluting stent: comparative analysis from a 10-year single-center experience .

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lee, Sahmin Yoon, Chang-Hwan Oh, Il-Young Suh, Jung-Won Cho, Young-Seok Cho, Goo-Yeong Chae, In-Ho Choi, Dong-Ju Youn, Tae-Jin
Spatial Coverage	Republic of Korea
Description	Author Affiliation: Lee S ( Cardiovascular Center and Department of Internal Medicine, Seoul National University Hospital.)
Abstract	The angiographic features of restenosis contain prognostic information. However, restenosis patterns of the new generation drug-eluting stents (DES), everolimus-(EES) and resolute zotarolimus-eluting stent (ZES) have not been described.A total of 210 consecutive patients with DES restenosis were enrolled from 2003 to 2012. We analyzed 217 restenotic lesions after DES implantation, and compared the morphologic characteristics of the 2nd generation DES restenosis to those of restenosis with 2 first generation DES, sirolimus-(SES) and paclitaxel-eluting stent (PES).Baseline characteristics were comparable between the different stent groups. The incidence of focal restenosis was significantly lower for PES than the other stents (49.5% versus 87.0%, 76.2%, and 82.1% for PES versus SES, EES, and ZES, respectively, P < 0.001). When considering the pattern of restenosis solely within the stent margins, a further clear distinction between PES and other stents was observed (40.0% versus 92.9%, 88.9%, and 81.2% in PES versus SES, EES, and ZES, respectively, P < 0.001). There were no significant differences in restenosis patterns among SES, EES, and ZES. In multivariate analysis, PES implantation, hypertension, and age were associated with non-focal type of restenosis after DES implantation. After the introduction of EES and ZES into routine clinical practice in 2008, focal restenosis significantly increased from 63.9% to 76.7% and diffuse restenosis significantly decreased from 26.4% to 11.0% (P = 0.045).Focal restenosis was the most common pattern of restenosis in the new generation DES and the incidence of diffuse restenosis significantly decreased with the introduction of the 2nd generation DES.
File Format	HTM / HTML
ISSN	13492365
e-ISSN	13493299
Journal	International Heart Journal
Issue Number	1
Volume Number	56
Language	English
Publisher	International Heart Journal Association
Publisher Date	2015-01-01
Publisher Place	Japan
Access Restriction	Open
Subject Keyword	Discipline Cardiology Coronary Artery Disease Coronary Restenosis Drug-eluting Stents Adverse Effects Paclitaxel Therapeutic Use Percutaneous Coronary Intervention Postoperative Complications Sirolimus Analogs & Derivatives Coronary Angiography Physiopathology Surgery Diagnosis Epidemiology Etiology Coronary Vessels Pathology Everolimus Immunosuppressive Agents Instrumentation Registries Vascular Patency Comparative Study Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

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Angiographic findings of everolimus-eluting as compared to sirolimus-eluting stents: angiographic sub-study from the Randomized Evaluation of Sirolimus-eluting versus Everolimus-eluting stent Trial (RESET).

Angiographic patterns of restenosis with 2nd generation drug-eluting stent: comparative analysis from a 10-year single-center experience .

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