NDLI: Impact of smoking on coronary microcirculatory resistance in patients with coronary artery disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Miyazaki, Toru Ashikaga, Takashi Ohigashi, Hirokazu Komura, Masatoshi Kobayashi, Kazuo Isobe, Mitsuaki
Spatial Coverage	Japan
Description	Country affiliation: Japan Author Affiliation: Miyazaki T ( Department of Cardiovascular Medicine, Kashiwa Municipal, Chiba)
Abstract	The aim of this study was to investigate the relationship between coronary microvascular function and smoking using the 3 parameters fractional flow reserve (FFR), coronary flow reserve (CFR(thermo)), and index of microcirculatory resistance (IMR) in patients with coronary artery disease (CAD). A total of 97 CAD patients with 148 intermediate stenotic lesions were divided into two groups: current and former smokers (Smokers: n = 54), and those who had never smoked (Non-smokers: n = 43). Coronary physiology measurements were made following coronary angiography at rest and during hyperemia induced with intravenous adenosine triphosphate. If a patient had several intermediate lesions, the lesion producing the largest IMR value and minimum FFR(myo) and CFR(thermo) value was selected. Averaged over all patients, the FFR(myo), CFR(thermo), and IMR values were 0.86 ± 0.10, 2.66 ± 1.50, and 20.8 ± 10.7, respectively. There was no significant correlation between FFR(myo) and IMR. There were no significant differences between smokers and non-smokers in FFR(myo) value (median: 0.85 [IQR: 0.74-0.90] versus 0.87 [IQR: 0.83-0.90], P = 0.15) and CFR(thermo) value (median: 1.90 [IQR: 1.56-3.16] versus 2.10 [IQR: 1.50-2.67] U, P = 0.95). The IMR value was significantly greater in smokers (median: 24.2 [IQR: 16.8-32.5] U versus 18.5 [IQR: 15.4-27.0] U, P = 0.04). In multivariate analysis, smoking was an independent predictor of increased IMR. Smoking appears to have a detrimental effect on coronary microvascular function as measured by IMR.
File Format	HTM / HTML
ISSN	13492365
e-ISSN	13493299
Journal	International Heart Journal
Issue Number	1
Volume Number	56
Language	English
Publisher	International Heart Journal Association
Publisher Date	2015-01-01
Publisher Place	Japan
Access Restriction	Open
Subject Keyword	Discipline Cardiology Coronary Artery Disease Coronary Circulation Physiology Coronary Vessels Microcirculation Microvessels Smoking Physiopathology Coronary Angiography Diagnosis Psychology Pathology Fractional Flow Reserve, Myocardial Retrospective Studies Statistics As Topic Vascular Resistance
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Vasodilatory capacity of the coronary microcirculation is preserved in selected patients with non-ST-segment-elevation myocardial infarction.

Integrated physiologic assessment of ischemic heart disease in real-world practice using index of microcirculatory resistance and fractional flow reserve: insights from the International Index of Microcirculatory Resistance Registry.

Long-term clinical outcome after fractional flow reserve-guided percutaneous coronary revascularization in patients with small-vessel disease.

Thermodilution-derived coronary microvascular resistance and flow reserve in patients with cardiac syndrome X.

When collateral supply is accounted for epicardial stenosis does not increase microvascular resistance.

Invasive coronary physiology for assessing intermediate lesions.

Invasive assessment of coronary microvascular dysfunction in hypertrophic cardiomyopathy: the index of microvascular resistance.

Coronary microcirculatory resistance is independent of epicardial stenosis.

Coronary flow reserve estimated by positron emission tomography to diagnose significant coronary artery disease and predict cardiac events.

Impact of smoking on coronary microcirculatory resistance in patients with coronary artery disease.

Similar Documents

Vasodilatory capacity of the coronary microcirculation is preserved in selected patients with non-ST-segment-elevation myocardial infarction.

Integrated physiologic assessment of ischemic heart disease in real-world practice using index of microcirculatory resistance and fractional flow reserve: insights from the International Index of Microcirculatory Resistance Registry.

Long-term clinical outcome after fractional flow reserve-guided percutaneous coronary revascularization in patients with small-vessel disease.

Thermodilution-derived coronary microvascular resistance and flow reserve in patients with cardiac syndrome X.

When collateral supply is accounted for epicardial stenosis does not increase microvascular resistance.

Invasive coronary physiology for assessing intermediate lesions.

Invasive assessment of coronary microvascular dysfunction in hypertrophic cardiomyopathy: the index of microvascular resistance.

Coronary microcirculatory resistance is independent of epicardial stenosis.

Coronary flow reserve estimated by positron emission tomography to diagnose significant coronary artery disease and predict cardiac events.

Impact of smoking on coronary microcirculatory resistance in patients with coronary artery disease.