NDLI: Novel isoform of the Xenopus tropicalis PKA catalytic alpha subunit: An example of alternative splicing.

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Year: 2010 Volume: 5 Issue: 1

Novel isoform of the Xenopus tropicalis PKA catalytic alpha subunit: An example of alternative splicing.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tabish, Mohammad Rodionov, Vladimir I.
Description	Author Affiliation: Tabish M ( University of Connecticut Health Center, Farmington, 06032, USA. tabish.biochem@gmail.com )
Abstract	The cAMP-dependent protein kinase (PKA) plays key roles in the control of various aspects of eukaryotic cellular activities by phosphorylating several proteins and is multifunctional in nature. In the case of frog, Xenopus tropicalis, a gene encoding the PKA catalytic alpha subunit has been identified which encodes a single protein. Here we report the occurrence of N-terminal alternative splicing events in X. tropicalis tadpole that, in addition to generating a myristoylatable isoforms, also generate the non-myristoylated variant of the catalytic alpha subunit as has been reported in various other organisms. In addition to the already characterized exon 1, the 5' untranslated region and first intron actually contains one more other exon, that is alternatively spliced on to exon 2 at the 5' end of the pre-mRNA. This N-terminal alternative splicing occurs in combination with already characterized all internal exons. Thus, X. tropicalis tadpole expresses at least two different isoforms of the catalytic alpha subunit of PKA. The significance of this structural diversity in the family of PKA catalytic subunits is discussed.
File Format	HTM / HTML
ISSN	1744117X
e-ISSN	18780407
DOI	10.1016/j.cbd.2010.03.006
Journal	Comparative Biochemistry and Physiology Part D: Genomics and Proteomics
Issue Number	2
Volume Number	5
Language	English
Publisher	Elsevier
Publisher Date	2010-06-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Genetics Discipline Biochemistry Alternative Splicing Cyclic Amp-dependent Protein Kinases Genetics Xenopus Metabolism Amino Acid Sequence Animals Catalytic Domain Chemistry Exons Molecular Sequence Data Protein Isoforms Sequence Alignment Xenopus Proteins Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Physiology Molecular Biology Biochemistry Aquatic Science Animal Science and Zoology

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