NDLI: Maternal supplementation of nucleotides improves the behavioral development of prenatal ethanol-exposed mice.

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Maternal supplementation of nucleotides improves the behavioral development of prenatal ethanol-exposed mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dong, Wenhong Wu, Zhenghao Xu, Linlin Fang, Yuehui Xu, Yajun
Description	Country affiliation: China Author Affiliation: Dong W ( Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, China.)
Abstract	Maternal ethanol consumption during pregnancy can induce learning deficits in the offspring. The objective of this study was to assess whether supplementation of exogenous nucleotides during pregnancy and lactation would ameliorate prenatal ethanol-induced learning and memory deficits in the offspring of mice, and to explore the possible mechanisms. In the present study, pregnant C57BL/6J mice were exposed to ethanol (5 g/kg body weight) intragastrically from gestational day (GD) 6 to GD15. The dams in exogenous nucleotide intervention groups were fed with feed containing 0.01%, 0.04%, or 0.16% nucleotide powder, with control and ethanol groups receiving normal feed. The dams were allowed to deliver naturally and to breast feed their offspring. After weaning, behavioral tests were carried out in the offspring of each group. Serum oxidation indexes were analyzed, and the hippocampus of each offspring was collected and detected for acetyl cholinesterase (AChE) activity and the expression of p-CREB, CREB, and BDNF. The results showed that maternal supplementation with exogenous nucleotides during pregnancy could ameliorate prenatal ethanol-induced learning and memory deficits in the offspring of mice, through improving their antioxidant capacity, reversing hippocampus AChE levels, and allowing the expression of some proteins related to learning and memory. However, different sensitivities were found between the two sexes.
File Format	HTM / HTML
ISSN	15307026
Issue Number	2
Volume Number	14
e-ISSN	1531135X
Journal	Cognitive, Affective, & Behavioral Neuroscience
Language	English
Publisher	Springer
Publisher Date	2014-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Behavioral Sciences Discipline Neurology Central Nervous System Depressants Toxicity Developmental Disabilities Etiology Prevention & Control Ethanol Nucleotides Administration & Dosage Prenatal Exposure Delayed Effects Acetylcholinesterase Metabolism Animals Animals, Newborn Body Weight Blood Escape Reaction Exploratory Behavior Female Glutathione Peroxidase Hippocampus Male Malondialdehyde Maze Learning Mice Mice, Inbred C57bl Pregnancy Physiopathology Superoxide Dismutase Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cognitive Neuroscience Behavioral Neuroscience

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