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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rostami, E. Bondi, M. |
| Description | Country affiliation: Sweden Author Affiliation: Rostami E ( Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. elham.rostami@ki.se) |
| Abstract | PURPOSE: The aim of this study is to investigate the effect of local activation of ß-adrenoreceptor by Isoprenaline on metabolism in brain, fat and lung measured by microdialysis. METHODS: We used 8 healthy pigs under general anaesthesia and placed microdialysis catheters in brain, fat, lung and artery. We performed a direct measurement of glucose, lactate, pyruvate and glycerol. The stimulation was performed by one-hour infusion of Isoprenaline, a ß-adrenoreceptor agonist. RESULTS: The infusion of isoprenaline did not affect the glucose in any tissue. The levels of lactate (p=0.008) and pyruvate (p=0.011) decreased significantly in lung after isoprenaline infusion. There was a significant increase in L/P ratio in fat tissue (p=0.001) while no significant changes could be found in brain (p=0.086) and lung (p=0.679). The most pronounced and significant change was observed in glycerol in fat (p<0.001) that increased by 95%. CONCLUSION: The prominent increase in glycerol in fat proved to be a good measure of ß-adrenoreceptor activation and a measure of lipolysis. This can be used to online monitor ß-adrenoreceptor activation by glycerol measurement in patients. |
| File Format | HTM / HTML |
| ISSN | 18961126 |
| Issue Number | 1 |
| Volume Number | 57 |
| e-ISSN | 18984002 |
| Journal | Advances in Medical Sciences |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-06-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Medicine Adipose Tissue Metabolism Brain Lung Microdialysis Methods Receptors, Adrenergic, Beta Animals Lipolysis Swine Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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