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Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Knapp, M. Baranowski, M. Lisowska, A. Musial, W.
Description	Country affiliation: Poland Author Affiliation: Knapp M ( Department of Cardiology, Medical University of Bialystok, Poland. malgo33@interia.pl)
Abstract	PURPOSE: In recent years, the role of sphingolipids in pathophysiology of the heart attracted much attention. Ceramide was found to be involved in the pathogenesis of cardiac dysfunction in animal models of ischemia/reperfusion injury, type 2 diabetes and lipotoxic cardiomyopathy. On the other hand, sphingosine-1-phosphate (S1P), has been shown to possess potent cardioprotective properties. The aim of the present study was to examine plasma concentrations of major sphingolipids in patients with chronic heart failure (HF). MATERIAL AND METHODS: The subjects were divided into two major groups: 1) with chronic systolic HF (n=47), and 2) healthy age-matched controls (n=15). Patients in the former group were further divided according to the underlying cause of HF (ischemic heart disease or idiopathic dilated cardiomyopathy, n=29 and 18, respectively). RESULTS: Plasma concentrations of S1P, sphinganine-1-phosphate and ceramide observed in both groups of HF patients were very close to these noted in the healthy controls, and no statistically significant differences were found. However, the level of free sphingosine and sphinganine in the plasma of patients with HF decreased by 25 and 27%, respectively, as compared to the control subjects. This effect was independent from the underlying cause of HF as the mean concentrations of these sphingoid bases in patients with ischemic and idiopathic HF were virtually the same. CONCLUSIONS: We conclude that chronic heart failure is associated with decreased concentration of free sphingoid bases in the plasma. However, despite lower availability of substrates required for synthesis of cardioprotective sphingoid base-1 phosphates, their plasma level remains stable.
File Format	HTM / HTML
ISSN	18961126
Issue Number	1
Volume Number	57
e-ISSN	18984002
Journal	Advances in Medical Sciences
Language	English
Publisher	Elsevier
Publisher Date	2012-06-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Medicine Heart Failure, Systolic Blood Cardiomyopathies Ceramides Female Humans Lysophospholipids Male Middle Aged Sphingosine Analogs & Derivatives Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine

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