NDLI: p16 gene mutations in Barrett's esophagus in gastric metaplasia - intestinal metaplasia - dysplasia

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p16 gene mutations in Barrett's esophagus in gastric metaplasia - intestinal metaplasia - dysplasia - adenocarcinoma sequence.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mokrowiecka, A. Wierzchniewska-Lawska, A. Smolarz, B. Romanowicz-Makowska, H. Malecka-Panas, E.
Description	Country affiliation: Poland Author Affiliation: Mokrowiecka A ( Department of Digestive Tract Diseases, Medical University of Lodz, Poland. annazlo@wp.pl)
Abstract	PURPOSE: Barrett's associated esophageal adenocarcinoma (ADC) is one of the malignancies of most rapidly increasing incidence. The aim of the study was to assess p16 tumor suppressor gene alterations in the ADC premalignant conditions. MATERIAL & METHODS: In the present study two p16 gene mutations (A148T and I49S) analysis with PCR- RFLP method have been performed in oesophageal biopsy specimen in 33 patients with Barrett's gastric metaplasia (GM), 27 - with Barrett's intestinal metaplasia (IM), 8 - with dysplasia and 11 - with ADC. RESULTS: We have detected the I49S mutation in 12% (4/33) patients with GM, 18% (5/27) with IM, 50% - with dysplasia (4/8) and in 27% (3/11) - with ADC. The A148T mutation were found in 3% (1/33) patients with GM, 22% (6/27) - IM, 25% (2/8) - dysplasia and 27% patients with ADC (3/11). The frequency of the A148S mutation was rising in GM - IM - dysplasia - ADC sequence and was significantly lower in GM compared to all other grades taken together (p=0.0256). The frequency of the I49S mutation was rising in GM - IM - dysplasia sequence, to drop in ADC cases. There were no significant differences in frequency of the I49S mutation between studied groups. CONCLUSIONS: These findings are consistent with the hypothesis on the role of the p16 mutations in early phase of Barrett's epithelium progression to ADC. The presence of p16 mutations in esophageal metaplastic columnar epithelium without goblet cells suggest that this pathology may have malignancy potential.
File Format	HTM / HTML
ISSN	18961126
Issue Number	1
Volume Number	57
e-ISSN	18984002
Journal	Advances in Medical Sciences
Language	English
Publisher	Elsevier
Publisher Date	2012-06-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Medicine Barrett Esophagus Genetics Genes, P16 Physiology Adult Aged Aged, 80 And Over Female Humans Intestinal Diseases Male Metaplasia Middle Aged Mutation Polymerase Chain Reaction Precancerous Conditions Stomach Diseases Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine

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