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Interleukin 6 is not necessary for STAT3 phosphorylation and myocardial hypertrophy following short term beta-adrenergic stimulation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kaminski, K. A. Dziemidowicz, M. Litvinovich, S. Bonda, T. Ptaszynska, K. Kozuch, M. Taranta, A. Musial, W. J. Winnicka, M. M.
Description	Country affiliation: Poland Author Affiliation: Kaminski KA ( Department of Cardiology, Medical University of Bialystok, Poland. fizklin@wp.pl)
Abstract	PURPOSE: In recent years several reports have suggested involvement of interleukin 6 (IL-6) in beta-adrenergic effects on myocardium, particularly in enhancement of STAT3 phosphorylation (downstream signal transducer of IL-6). Here we present a study of isoproterenol effects on hearts of IL-6 deficient mice. METHODS: Male 12 week old C57Bl6/J mice and age and sex matched mice from IL-6 knockout strain (C57Bl6/J(IL6-/-)) received a single intraperitoneal bolus of either isoproterenol (15 mg/kg) or placebo (0.9% NaCl) and were sacrificed after 1 or 24 hours (n=8 in each group). Another group of mice from both genotypes received a three-day isoproterenol treatment (20 mg/kg every 8h). Activation of STAT3 and MEK/ERK pathways were assessed after a single dose of isoproterenol by means of western blotting. RESULTS: After injection of placebo a significantly lower level of STAT3 phosphorylation was observed in IL-6 KO animals. This difference was abolished after isoproterenol both at 1 and 24-hour time points. Isoproterenol produced potent and rapid activation of both STAT3 and MEK/ERK pathways that returned to the levels of placebo treated controls after 24 hours. Lack of IL-6 did not affect phosphorylation of ERKs. Three-day treatment with isoproterenol caused significant increase of indices of RV and LV hypertrophy in both WT and IL-6 KO animals with no significant differences between genotypes. CONCLUSION: IL-6 is not necessary for isoproterenol induced STAT3 phosphorylation, but may affect activation of this pathway by mild non-specific stimuli. Lack of IL-6 does not affect activation of MEK/ERK pathway nor cardiac hypertrophy by beta-adrenergic agonists.
File Format	HTM / HTML
ISSN	18961126
Issue Number	1
Volume Number	57
e-ISSN	18984002
Journal	Advances in Medical Sciences
Language	English
Publisher	Elsevier
Publisher Date	2012-06-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Medicine Adrenergic Beta-agonists Pharmacology Hypertrophy Metabolism Interleukin-6 Myocardium Stat3 Transcription Factor Animals Genetics Isoproterenol Male Mice Mice, Inbred C57bl Mice, Knockout Phosphorylation Drug Effects Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine

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