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Interplay of cytokine polymorphisms and bacterial vaginosis in the etiology of preterm delivery.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jones, Nicole M. Holzman, Claudia Friderici, Karen H. Jernigan, Katherine Chung, Hwan Wirth, Julia Fisher, Rachel
Description	Country affiliation: United States Author Affiliation: Jones NM ( Department of Epidemiology, B601 West Fee Hall, Michigan State University, East Lansing, MI 48824, USA. njones@epi.msu.edu)
Abstract	Recent findings suggest that the association between inflammation-related genes and preterm delivery may be stronger in the presence of bacterial vaginosis (BV). Tumor necrosis factor-alpha (TNF ) and interleukin 1-beta (IL-1ß) are pro-inflammatory cytokines capable of inducing preterm labor in non-human primates. In this study the authors tested associations among two TNF promoter polymorphisms (-G308A and -G238A), a single IL-1ß polymorphism (+C3954T), vaginal microbial findings, and risk of preterm delivery. Data were from the Pregnancy Outcomes and Community Health (POUCH) Study (n=777 term and n=230 preterm deliveries). Vaginal smears collected at mid-pregnancy (15-27 weeks gestation) were scored according to Nugent's criteria. A Nugent score of ≥ 4 was modeled as the cut-point for intermediate and positive BV. Logistic regression was used to estimate odds ratios for associations among independent covariates (vaginal flora, genotype) and preterm delivery. Results showed that women with a Nugent score of≥ 4 and the TNF -238 A/G or A/A were at increased risk of delivering preterm (race/ethnicity adjusted OR 2.6, 95% CI 1.2, 5.8). The p-value for the genotype and Nugent score interaction=0.02. This study points to one more example of a potential gene-environment interaction in a preterm delivery pathway. Future tests of this finding will determine the robustness of these results.
File Format	HTM / HTML
ISSN	01650378
e-ISSN	18727603
DOI	10.1016/j.jri.2010.06.158
Journal	Journal of Reproductive Immunology
Issue Number	1-2
Volume Number	87
Language	English
Publisher	Elsevier
Publisher Date	2010-12-01
Publisher Place	Ireland
Access Restriction	Open
Subject Keyword	Discipline Immunology Discipline Reproductive Medicine Premature Birth Etiology Tumor Necrosis Factor-alpha Genetics Vaginosis, Bacterial Complications Cohort Studies Cytokines Genotype Interleukin-1beta Polymorphism, Single Nucleotide Pregnancy Pregnancy Outcome Microbiology Risk Factors Vagina Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, P.h.s.
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Reproductive Medicine Obstetrics and Gynecology

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Interplay of cytokine polymorphisms and bacterial vaginosis in the etiology of preterm delivery.

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