NDLI: Peripheral blood invariant natural killer T cells throughout pregnancy and in preeclamptic women.

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Peripheral blood invariant natural killer T cells throughout pregnancy and in preeclamptic women.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Southcombe, Jennifer Redman, Chris Sargent, Ian
Description	Country affiliation: United kingdom Author Affiliation: Southcombe J ( Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. jen.southcombe@obs-gyn.ox.ac.uk)
Abstract	Invariant natural killer T (iNKT) cells are implicated in the pathogenesis of several diseases. They influence both innate and adaptive immune responses through their capacity to rapidly produce large quantities of cytokines upon activation. During pregnancy maternal immunity is biased towards type 2 cytokine production to regulate type 1 cytokines that could be harmful for the developing fetus. This shift to type 2 cytokines does not occur in preeclamptic women and there is an exaggerated maternal inflammatory response which is dangerous for both mother and baby. We have therefore investigated the numbers, phenotype and functional activity of iNKT cells throughout pregnancy and in women diagnosed with preeclampsia. We demonstrate that the numbers of iNKT cells in the peripheral blood do not change between the first, second and third trimesters of pregnancy, but the cells become activated and less able to produce the type 1 cytokine IFNÎ³. However, iNKT cells are unchanged in preeclamptic women, when compared to normal pregnancy, suggesting that these cells are not primary players in the pathogenesis of the disease.
File Format	HTM / HTML
ISSN	01650378
e-ISSN	18727603
DOI	10.1016/j.jri.2010.07.003
Journal	Journal of Reproductive Immunology
Issue Number	1-2
Volume Number	87
Language	English
Publisher	Elsevier
Publisher Date	2010-12-01
Publisher Place	Ireland
Access Restriction	Open
Subject Keyword	Discipline Immunology Discipline Reproductive Medicine Interferon-gamma Biosynthesis Lymphocyte Activation Natural Killer T-cells Immunology Pre-eclampsia Pregnancy Antigens, Cd Genetics Antigens, Cd4 Antigens, Cd8 Antigens, Differentiation, T-lymphocyte Flow Cytometry Metabolism Lectins, C-type Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Reproductive Medicine Obstetrics and Gynecology

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